diff --git a/pkgs/tools/networking/vde2/default.nix b/pkgs/tools/networking/vde2/default.nix
index babbd88fd16..bc3be912265 100644
--- a/pkgs/tools/networking/vde2/default.nix
+++ b/pkgs/tools/networking/vde2/default.nix
@@ -22,6 +22,10 @@ stdenv.mkDerivation rec {
     })
   ];
 
+  preConfigure = lib.optionalString (lib.versionAtLeast stdenv.hostPlatform.darwinMinVersion "11") ''
+    MACOSX_DEPLOYMENT_TARGET=10.16
+  '';
+
   configureFlags = lib.optional (!withPython) "--disable-python";
 
   buildInputs = [ openssl libpcap ]