diff --git a/pkgs/development/python-modules/flask-appbuilder/default.nix b/pkgs/development/python-modules/flask-appbuilder/default.nix
index 0129c987723..1d84fb88ed7 100644
--- a/pkgs/development/python-modules/flask-appbuilder/default.nix
+++ b/pkgs/development/python-modules/flask-appbuilder/default.nix
@@ -27,7 +27,7 @@
 
 buildPythonPackage rec {
   pname = "flask-appbuilder";
-  version = "3.4.4";
+  version = "4.0.0";
   format = "setuptools";
 
   disabled = pythonOlder "3.7";
@@ -35,14 +35,10 @@ buildPythonPackage rec {
   src = fetchPypi {
     pname = "Flask-AppBuilder";
     inherit version;
-    sha256 = "sha256-uZzuvNusqMzAS/vmg3CuZ+D442J4LbFwsBboVIx/srE=";
+    hash = "sha256-g+iHUL83PokXPGu7HJ8ffLocQr0uGpMqS5MbfIlZZ2E=";
   };
 
-  # See here: https://github.com/dpgaspar/Flask-AppBuilder/commit/7097a7b133f27c78d2b54d2a46e4a4c24478a066.patch
-  #           https://github.com/dpgaspar/Flask-AppBuilder/pull/1610
-  # The patch from the PR doesn't apply cleanly so I edited it manually.
   patches = [
-    ./upgrade-to-flask_jwt_extended-4.patch
     (fetchpatch {
       # https://github.com/dpgaspar/Flask-AppBuilder/pull/1734
       name = "flask-appbuilder-wtf3.patch";
@@ -82,16 +78,11 @@ buildPythonPackage rec {
   postPatch = ''
     substituteInPlace setup.py \
       --replace "apispec[yaml]>=3.3, <4" "apispec[yaml] >=3.3" \
-      --replace "Flask>=0.12, <2" "Flask" \
-      --replace "Flask-Login>=0.3, <0.5" "Flask-Login >=0.3, <0.6" \
-      --replace "Flask-Babel>=1, <2" "Flask-Babel >=1, <3" \
+      --replace "Flask-Login>=0.3, <0.5" "Flask-Login >=0.3" \
       --replace "Flask-WTF>=0.14.2, <0.15.0" "Flask-WTF" \
       --replace "WTForms<3.0.0" "WTForms" \
       --replace "marshmallow-sqlalchemy>=0.22.0, <0.27.0" "marshmallow-sqlalchemy" \
-      --replace "Flask-JWT-Extended>=3.18, <4" "Flask-JWT-Extended>=4.1.0" \
-      --replace "PyJWT>=1.7.1, <2.0.0" "PyJWT>=2.0.1" \
-      --replace "prison>=0.2.1, <1.0.0" "prison" \
-      --replace "SQLAlchemy<1.4.0" "SQLAlchemy"
+      --replace "prison>=0.2.1, <1.0.0" "prison"
   '';
 
   # Majority of tests require network access or mongo