diff --git a/pkgs/development/web/nodejs/v16.nix b/pkgs/development/web/nodejs/v16.nix
index 2f044b44f21..89b6c3e4363 100644
--- a/pkgs/development/web/nodejs/v16.nix
+++ b/pkgs/development/web/nodejs/v16.nix
@@ -1,4 +1,4 @@
-{ callPackage, openssl, python3, enableNpm ? true }:
+{ callPackage, openssl, python3, fetchpatch, enableNpm ? true }:
 
 let
   buildNodejs = callPackage ./nodejs.nix {
@@ -8,9 +8,17 @@ let
 in
   buildNodejs {
     inherit enableNpm;
-    version = "16.15.0"; # Do not upgrade until #176127 is solved
-    sha256 = "sha256-oPgS78Q/eDIeygiVeWCkj15r+XAE1QWMjdOwPGRupPc=";
+    version = "16.16.0";
+    sha256 = "sha256-FFFR7/Oyql6+czhACcUicag3QK5oepPJjGKM19UnNus=";
     patches = [
       ./disable-darwin-v8-system-instrumentation.patch
+      # Fix npm silently fail without a HOME directory https://github.com/npm/cli/issues/4996
+      (fetchpatch {
+        url = "https://github.com/npm/cli/commit/9905d0e24c162c3f6cc006fa86b4c9d0205a4c6f.patch";
+        sha256 = "sha256-RlabXWtjzTZ5OgrGf4pFkolonvTDIPlzPY1QcYDd28E=";
+        includes = [ "deps/npm/lib/npm.js" "deps/npm/lib/utils/log-file.js" ];
+        stripLen = 1;
+        extraPrefix = "deps/npm/";
+      })
     ];
   }