diff --git a/nixos/tests/zigbee2mqtt.nix b/nixos/tests/zigbee2mqtt.nix
new file mode 100644
index 00000000000..b7bb21f9227
--- /dev/null
+++ b/nixos/tests/zigbee2mqtt.nix
@@ -0,0 +1,19 @@
+import ./make-test-python.nix ({ pkgs, ... }:
+
+  {
+    machine = { pkgs, ... }:
+      {
+        services.zigbee2mqtt = {
+          enable = true;
+        };
+      };
+
+    testScript = ''
+      machine.wait_for_unit("zigbee2mqtt.service")
+      machine.wait_until_fails("systemctl status zigbee2mqtt.service")
+      machine.succeed(
+          "journalctl -eu zigbee2mqtt | grep \"Error: Error while opening serialport 'Error: Error: No such file or directory, cannot open /dev/ttyACM0'\""
+      )
+    '';
+  }
+)