diff --git a/pkgs/development/ocaml-modules/ocplib-endian/default.nix b/pkgs/development/ocaml-modules/ocplib-endian/default.nix
index 1e657fce8dd..285e8de84b3 100644
--- a/pkgs/development/ocaml-modules/ocplib-endian/default.nix
+++ b/pkgs/development/ocaml-modules/ocplib-endian/default.nix
@@ -1,4 +1,4 @@
-{ lib, buildDunePackage, fetchFromGitHub, cppo }:
+{ lib, buildDunePackage, fetchFromGitHub, ocaml, cppo }:
 
 buildDunePackage rec {
   version = "1.2";
@@ -11,6 +11,11 @@ buildDunePackage rec {
     sha256 = "sha256-THTlhOfXAPaqTt1qBkht+D67bw6M175QLvXoUMgjks4=";
   };
 
+  postPatch = lib.optionalString (lib.versionAtLeast ocaml.version "5.0") ''
+    substituteInPlace src/dune \
+      --replace "libraries ocplib_endian bigarray" "libraries ocplib_endian"
+  '';
+
   minimalOCamlVersion = "4.03";
 
   nativeBuildInputs = [ cppo ];