diff --git a/pkgs/development/python-modules/systemd/default.nix b/pkgs/development/python-modules/systemd/default.nix
index 7c6bb41cfdd..b27af96edbd 100644
--- a/pkgs/development/python-modules/systemd/default.nix
+++ b/pkgs/development/python-modules/systemd/default.nix
@@ -1,5 +1,6 @@
 { lib
 , buildPythonPackage
+, fetchpatch
 , fetchFromGitHub
 , systemd
 , pkg-config
@@ -16,6 +17,15 @@ buildPythonPackage rec {
     sha256 = "1fakw7qln44mfd6pj4kqsgyrhkc6cyr653id34kv0rdnb1bvysrz";
   };
 
+  patches = [
+    # Fix runtime issues on Python 3.10
+    # https://github.com/systemd/python-systemd/issues/107
+    (fetchpatch {
+      url = "https://github.com/systemd/python-systemd/commit/c71bbac357f0ac722e1bcb2edfa925b68cca23c9.patch";
+      sha256 = "22s72Wa/BCwNNvwbxEUh58jhHlbA00SNwNVchVDovcc=";
+    })
+  ];
+
   nativeBuildInputs = [
     pkg-config
   ];