diff --git a/pkgs/development/libraries/webkitgtk/default.nix b/pkgs/development/libraries/webkitgtk/default.nix
index 57168b2cc17..1db2f4ce6d8 100644
--- a/pkgs/development/libraries/webkitgtk/default.nix
+++ b/pkgs/development/libraries/webkitgtk/default.nix
@@ -27,6 +27,7 @@
 , libxkbcommon
 , libavif
 , libepoxy
+, libjxl
 , at-spi2-core
 , libxml2
 , libsoup
@@ -34,7 +35,6 @@
 , libxslt
 , harfbuzz
 , libpthreadstubs
-, pcre
 , nettle
 , libtasn1
 , p11-kit
@@ -51,7 +51,6 @@
 , openjpeg
 , geoclue2
 , sqlite
-, enableGLES ? true
 , gst-plugins-base
 , gst-plugins-bad
 , woff2
@@ -71,7 +70,7 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "webkitgtk";
-  version = "2.40.5";
+  version = "2.42.1";
   name = "${finalAttrs.pname}-${finalAttrs.version}+abi=${if lib.versionAtLeast gtk3.version "4.0" then "6.0" else "4.${if lib.versions.major libsoup.version == "2" then "0" else "1"}"}";
 
   outputs = [ "out" "dev" "devdoc" ];
@@ -82,7 +81,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   src = fetchurl {
     url = "https://webkitgtk.org/releases/webkitgtk-${finalAttrs.version}.tar.xz";
-    hash = "sha256-feBRomNmhiHZGmGl6xw3cdGnzskABD1K/vBsMmwWA38=";
+    hash = "sha256-b0H6yZidPuUcCMSN4dQ5ze3ey8dX40thgJh9mbFtJJk=";
   };
 
   patches = lib.optionals stdenv.isLinux [
@@ -132,6 +131,7 @@ stdenv.mkDerivation (finalAttrs: {
     enchant2
     libavif
     libepoxy
+    libjxl
     gnutls
     gst-plugins-bad
     gst-plugins-base
@@ -153,7 +153,6 @@ stdenv.mkDerivation (finalAttrs: {
     nettle
     openjpeg
     p11-kit
-    pcre
     sqlite
     woff2
   ] ++ (with xorg; [
@@ -219,8 +218,6 @@ stdenv.mkDerivation (finalAttrs: {
     "-DUSE_GTK4=ON"
   ] ++ lib.optionals (!systemdSupport) [
     "-DENABLE_JOURNALD_LOG=OFF"
-  ] ++ lib.optionals (stdenv.isLinux && enableGLES) [
-    "-DENABLE_GLES2=ON"
   ];
 
   postPatch = ''
diff --git a/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch b/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch
index f46c0fe8a15..48e7d9cca74 100644
--- a/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch
+++ b/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch
@@ -3,7 +3,7 @@
 @@ -84,7 +84,7 @@ void WebProcessPool::platformInitializeWebProcess(const WebProcessProxy& process
  
  #if PLATFORM(WAYLAND)
-     if (WebCore::PlatformDisplay::sharedDisplay().type() == WebCore::PlatformDisplay::Type::Wayland) {
+     if (WebCore::PlatformDisplay::sharedDisplay().type() == WebCore::PlatformDisplay::Type::Wayland && parameters.dmaBufRendererBufferMode.isEmpty()) {
 -        wpe_loader_init("libWPEBackend-fdo-1.0.so.1");
 +        wpe_loader_init("@wpebackend_fdo@/lib/libWPEBackend-fdo-1.0.so.1");
          if (AcceleratedBackingStoreWayland::checkRequirements()) {