diff --git a/pkgs/development/libraries/zydis/default.nix b/pkgs/development/libraries/zydis/default.nix
index 901d32b3959..c1b2c760dd2 100644
--- a/pkgs/development/libraries/zydis/default.nix
+++ b/pkgs/development/libraries/zydis/default.nix
@@ -1,9 +1,16 @@
 { lib
 , stdenv
 , fetchFromGitHub
+, callPackage
 , cmake
+, python3
 }:
 
+let
+  zycore = callPackage ./zycore.nix {
+    inherit stdenv fetchFromGitHub cmake;
+  };
+in
 stdenv.mkDerivation rec {
   pname = "zydis";
   version = "4.0.0";
@@ -12,14 +19,29 @@ stdenv.mkDerivation rec {
     owner = "zyantific";
     repo = "zydis";
     rev = "v${version}";
-    fetchSubmodules = true;
-    sha256 = "sha256-WSBi8HUVj/JR0/0pBoEaUKD0kOk41gSW5ZW74fn8b4k=";
+    hash = "sha256-/no/8FNa5LlwhZMSMao4/cwZk6GlamLjqr+isbh6tEI=";
   };
 
-  nativeBuildInputs = [
-    cmake
+  nativeBuildInputs = [ cmake ];
+  buildInputs = [ zycore ];
+  cmakeFlags = [
+    "-DZYAN_SYSTEM_ZYCORE=ON"
+    "-DCMAKE_INSTALL_LIBDIR=lib"
+    "-DCMAKE_INSTALL_INCLUDEDIR=include"
   ];
 
+  doCheck = true;
+  checkInputs = [ python3 ];
+  checkPhase = ''
+    pushd ../tests
+    python3 ./regression.py test ../build/ZydisInfo
+    python3 ./regression_encoder.py \
+      ../build/Zydis{Fuzz{ReEncoding,Encoder},TestEncoderAbsolute}
+    popd
+  '';
+
+  passthru = { inherit zycore; };
+
   meta = with lib; {
     homepage = "https://zydis.re/";
     description = "Fast and lightweight x86/x86-64 disassembler library";
diff --git a/pkgs/development/libraries/zydis/zycore.nix b/pkgs/development/libraries/zydis/zycore.nix
new file mode 100644
index 00000000000..c0ad668d122
--- /dev/null
+++ b/pkgs/development/libraries/zydis/zycore.nix
@@ -0,0 +1,25 @@
+{ stdenv
+, fetchFromGitHub
+, cmake
+}:
+
+stdenv.mkDerivation rec {
+  pname = "zycore";
+  version = "1.4.1";
+
+  src = fetchFromGitHub {
+    owner = "zyantific";
+    repo = "zycore-c";
+    rev = "v${version}";
+    hash = "sha256-kplUgrYecymGxz92tEU6H+NNtcN/Ao/tmmqdVo2c7HA=";
+  };
+
+  nativeBuildInputs = [ cmake ];
+
+  # The absolute paths set by the Nix CMake build manager confuse
+  # Zycore's config generation (which appends them to the package path).
+  cmakeFlags = [
+    "-DCMAKE_INSTALL_LIBDIR=lib"
+    "-DCMAKE_INSTALL_INCLUDEDIR=include"
+  ];
+}