diff --git a/pkgs/applications/science/molecular-dynamics/gromacs/default.nix b/pkgs/applications/science/molecular-dynamics/gromacs/default.nix
index d08c15dd8a6..fe7a0030175 100644
--- a/pkgs/applications/science/molecular-dynamics/gromacs/default.nix
+++ b/pkgs/applications/science/molecular-dynamics/gromacs/default.nix
@@ -1,7 +1,8 @@
 { lib, stdenv, fetchurl, cmake, hwloc, fftw, perl, blas, lapack, mpi, cudatoolkit
 , singlePrec ? true
+, config
 , enableMpi ? false
-, enableCuda ? false
+, enableCuda ? config.cudaSupport or false
 , cpuAcceleration ? null
 }:
 
diff --git a/pkgs/development/libraries/elpa/default.nix b/pkgs/development/libraries/elpa/default.nix
index 65e83437f6b..73ebf218ee3 100644
--- a/pkgs/development/libraries/elpa/default.nix
+++ b/pkgs/development/libraries/elpa/default.nix
@@ -4,10 +4,11 @@
 , avxSupport ? stdenv.hostPlatform.avxSupport
 , avx2Support ? stdenv.hostPlatform.avx2Support
 , avx512Support ? stdenv.hostPlatform.avx512Support
+, config
 # Enable NIVIA GPU support
 # Note, that this needs to be built on a system with a GPU
 # present for the tests to succeed.
-, enableCuda ? false
+, enableCuda ? config.cudaSupport or false
 # type of GPU architecture
 , nvidiaArch ? "sm_60"
 , cudatoolkit
diff --git a/pkgs/development/libraries/hwloc/default.nix b/pkgs/development/libraries/hwloc/default.nix
index fbef44bf67e..8159f31bbbb 100644
--- a/pkgs/development/libraries/hwloc/default.nix
+++ b/pkgs/development/libraries/hwloc/default.nix
@@ -2,7 +2,8 @@
 , x11Support ? false
 , libX11
 , cairo
-, enableCuda ? false
+, config
+, enableCuda ? config.cudaSupport or false
 , cudaPackages
 }:
 
diff --git a/pkgs/development/libraries/science/chemistry/openmm/default.nix b/pkgs/development/libraries/science/chemistry/openmm/default.nix
index 2ad84249758..8b25554c4ab 100644
--- a/pkgs/development/libraries/science/chemistry/openmm/default.nix
+++ b/pkgs/development/libraries/science/chemistry/openmm/default.nix
@@ -11,7 +11,8 @@
 , enableOpencl ? true
 , opencl-headers
 , ocl-icd
-, enableCuda ? false
+, config
+, enableCuda ? config.cudaSupport or false
 , cudaPackages
 , addOpenGLRunpath
 }:
diff --git a/pkgs/development/libraries/ucc/default.nix b/pkgs/development/libraries/ucc/default.nix
index 56cebc08dcc..1c1804e9004 100644
--- a/pkgs/development/libraries/ucc/default.nix
+++ b/pkgs/development/libraries/ucc/default.nix
@@ -1,5 +1,6 @@
 { stdenv, lib, fetchFromGitHub, libtool, automake, autoconf, ucx
-, enableCuda ? false
+, config
+, enableCuda ? config.cudaSupport or false
 , cudatoolkit
 , enableAvx ? stdenv.hostPlatform.avxSupport
 , enableSse41 ? stdenv.hostPlatform.sse4_1Support
diff --git a/pkgs/games/katago/default.nix b/pkgs/games/katago/default.nix
index cc49d6338a6..3d0b5a141c3 100644
--- a/pkgs/games/katago/default.nix
+++ b/pkgs/games/katago/default.nix
@@ -1,6 +1,7 @@
 { stdenv
 , boost
 , cmake
+, config
 , cudaPackages
 , eigen
 , fetchFromGitHub
@@ -14,7 +15,7 @@
 , openssl
 , writeShellScriptBin
 , enableAVX2 ? stdenv.hostPlatform.avx2Support
-, backend ? "opencl"
+, backend ? if (config.cudaSupport or false) then "cuda" else "opencl"
 , enableBigBoards ? false
 , enableContrib ? false
 , enableTcmalloc ? true
diff --git a/pkgs/tools/compression/zfp/default.nix b/pkgs/tools/compression/zfp/default.nix
index 2d3890484e7..487cd02eb59 100644
--- a/pkgs/tools/compression/zfp/default.nix
+++ b/pkgs/tools/compression/zfp/default.nix
@@ -1,6 +1,7 @@
 { cmake, cudatoolkit, fetchFromGitHub, gfortran, lib, llvmPackages, python3Packages, stdenv
+, config
 , enableCfp ? true
-, enableCuda ? false
+, enableCuda ? config.cudaSupport or false
 , enableFortran ? builtins.elem stdenv.targetPlatform.system gfortran.meta.platforms
 , enableOpenMP ? true
 , enablePython ? true