diff --git a/pkgs/development/python-modules/griffe/default.nix b/pkgs/development/python-modules/griffe/default.nix
new file mode 100644
index 00000000000..e13143f88e6
--- /dev/null
+++ b/pkgs/development/python-modules/griffe/default.nix
@@ -0,0 +1,60 @@
+{ lib
+, aiofiles
+, buildPythonApplication
+, cached-property
+, fetchFromGitHub
+, git
+, pdm-pep517
+, pytestCheckHook
+, pythonOlder
+}:
+
+buildPythonApplication rec {
+  pname = "griffe";
+  version = "0.21.0";
+  format = "pyproject";
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "mkdocstrings";
+    repo = pname;
+    rev = version;
+    hash = "sha256-yhhEcPwh1AjMtDlPZVDR69WX/728wuKqdJdc+yv/o4c=";
+  };
+
+  nativeBuildInputs = [
+    pdm-pep517
+  ];
+
+  propagatedBuildInputs = lib.optionals (pythonOlder "3.8") [
+    cached-property
+  ];
+
+  checkInputs = [
+    git
+    pytestCheckHook
+  ];
+
+  passthru.optional-dependencies = {
+    async = [
+      aiofiles
+    ];
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  pythonImportsCheck = [
+    "griffe"
+  ];
+
+  meta = with lib; {
+    description = "Signatures for entire Python programs";
+    homepage = "https://github.com/mkdocstrings/griffe";
+    license = licenses.isc;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 40042ed7052..20b881d9aff 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -3787,6 +3787,8 @@ in {
 
   gridnet = callPackage ../development/python-modules/gridnet { };
 
+  griffe = callPackage ../development/python-modules/griffe { };
+
   grip = callPackage ../development/python-modules/grip { };
 
   groestlcoin_hash = callPackage ../development/python-modules/groestlcoin_hash { };