diff --git a/pkgs/development/libraries/simpleitk/default.nix b/pkgs/development/libraries/simpleitk/default.nix
index 2ae8b28b64f..c38257dadb0 100644
--- a/pkgs/development/libraries/simpleitk/default.nix
+++ b/pkgs/development/libraries/simpleitk/default.nix
@@ -1,17 +1,17 @@
-{ lib, stdenv, fetchFromGitHub, cmake, swig, lua, itk }:
+{ lib, stdenv, fetchFromGitHub, cmake, swig4, lua, itk }:
 
 stdenv.mkDerivation rec {
   pname = "simpleitk";
-  version = "2.0.2";
+  version = "2.1.1";
 
   src = fetchFromGitHub {
     owner = "SimpleITK";
     repo = "SimpleITK";
     rev = "v${version}";
-    sha256 = "1q51jmd6skrr31avxlrxx433lawc838ilzrj5vvv38a9f4gl45v8";
+    sha256 = "0ShUo9UVkliROIIR5bJtqlzESByfq9SQ1+Hy/40vJ50=";
   };
 
-  nativeBuildInputs = [ cmake swig ];
+  nativeBuildInputs = [ cmake swig4 ];
   buildInputs = [ lua itk ];
 
   # 2.0.0: linker error building examples
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 71d860fe0e2..5f951d1ff27 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -19693,7 +19693,7 @@ with pkgs;
 
   simp_le = callPackage ../tools/admin/simp_le { };
 
-  simpleitk = callPackage ../development/libraries/simpleitk { };
+  simpleitk = callPackage ../development/libraries/simpleitk { lua = lua5_3; };
 
   sfml = callPackage ../development/libraries/sfml {
     inherit (darwin.apple_sdk.frameworks) IOKit Foundation AppKit OpenAL;