diff --git a/pkgs/tools/filesystems/moosefs/default.nix b/pkgs/tools/filesystems/moosefs/default.nix
index e38b040ec0d..ee0d5eedc92 100644
--- a/pkgs/tools/filesystems/moosefs/default.nix
+++ b/pkgs/tools/filesystems/moosefs/default.nix
@@ -24,14 +24,30 @@ stdenv.mkDerivation rec {
   buildInputs =
     [ fuse libpcap zlib python ];
 
+  buildFlags = lib.optionals stdenv.isDarwin [ "CPPFLAGS=-UHAVE_STRUCT_STAT_ST_BIRTHTIME" ];
+
+  # Fix the build on macOS with macFUSE installed
+  postPatch = lib.optionalString stdenv.isDarwin ''
+    substituteInPlace configure --replace \
+      "/usr/local/lib/pkgconfig" "/nonexistent"
+  '';
+
+  preBuild = lib.optional stdenv.isDarwin ''
+    substituteInPlace config.h --replace \
+      "#define HAVE_STRUCT_STAT_ST_BIRTHTIME 1" \
+      "#undef HAVE_STRUCT_STAT_ST_BIRTHTIME"
+  '';
+
   postInstall = ''
     substituteInPlace $out/sbin/mfscgiserv --replace "datapath=\"$out" "datapath=\""
   '';
 
+  doCheck = true;
+
   meta = with lib; {
     homepage = "https://moosefs.com";
     description = "Open Source, Petabyte, Fault-Tolerant, Highly Performing, Scalable Network Distributed File System";
-    platforms = platforms.linux;
+    platforms = platforms.unix;
     license = licenses.gpl2;
     maintainers = [ maintainers.mfossen ];
   };