diff --git a/pkgs/development/python-modules/pyside6/default.nix b/pkgs/development/python-modules/pyside6/default.nix
index be99c0a086f..e0351674252 100644
--- a/pkgs/development/python-modules/pyside6/default.nix
+++ b/pkgs/development/python-modules/pyside6/default.nix
@@ -1,5 +1,6 @@
 { lib
 , stdenv
+, fetchpatch2
 , cmake
 , ninja
 , python
@@ -15,6 +16,15 @@ stdenv.mkDerivation rec {
 
   sourceRoot = "pyside-setup-everywhere-src-${version}/sources/${pname}";
 
+  patches = [
+    # Needed to build against qt 6.5.3, until pyside 6.5.3 is released
+    (fetchpatch2 {
+      url = "https://code.qt.io/cgit/pyside/pyside-setup.git/patch/sources/pyside6?id=63ef7628091c8827e3d0d688220d3ae165587eb2";
+      hash = "sha256-TN1xdBkrzZhNontShMC1SKyJK6a8fOk/Di3zX3kv5+I=";
+      stripLen = 2;
+    })
+  ];
+
   # FIXME: cmake/Macros/PySideModules.cmake supposes that all Qt frameworks on macOS
   # reside in the same directory as QtCore.framework, which is not true for Nix.
   postPatch = lib.optionalString stdenv.isLinux ''