diff --git a/doc/languages-frameworks/gnome.section.md b/doc/languages-frameworks/gnome.section.md
index 0d4865b7af1..3c8539ac424 100644
--- a/doc/languages-frameworks/gnome.section.md
+++ b/doc/languages-frameworks/gnome.section.md
@@ -116,10 +116,6 @@ For convenience, it also adds `dconf.lib` for a GIO module implementing a GSetti
 
 - []{#ssec-gnome-hooks-gobject-introspection} `gobject-introspection` setup hook populates `GI_TYPELIB_PATH` variable with `lib/girepository-1.0` directories of dependencies, which is then added to wrapper by `wrapGAppsHook`. It also adds `share` directories of dependencies to `XDG_DATA_DIRS`, which is intended to promote GIR files but it also [pollutes the closures](https://github.com/NixOS/nixpkgs/issues/32790) of packages using `wrapGAppsHook`.
 
-  ::: {.warning}
-  The setup hook [currently](https://github.com/NixOS/nixpkgs/issues/56943) does not work in expressions with `strictDeps` enabled, like Python packages. In those cases, you will need to disable it with `strictDeps = false;`.
-  :::
-
 - []{#ssec-gnome-hooks-gst-grl-plugins} Setup hooks of `gst_all_1.gstreamer` and `grilo` will populate the `GST_PLUGIN_SYSTEM_PATH_1_0` and `GRL_PLUGIN_PATH` variables, respectively, which will then be added to the wrapper by `wrapGAppsHook`.
 
 You can also pass additional arguments to `makeWrapper` using `gappsWrapperArgs` in `preFixup` hook:
diff --git a/pkgs/applications/audio/blanket/default.nix b/pkgs/applications/audio/blanket/default.nix
index 4662002c95e..5a3d9949f8c 100644
--- a/pkgs/applications/audio/blanket/default.nix
+++ b/pkgs/applications/audio/blanket/default.nix
@@ -31,13 +31,13 @@ python3Packages.buildPythonApplication rec {
     pkg-config
     wrapGAppsHook4
     desktop-file-utils
+    gobject-introspection
   ];
 
   buildInputs = [
     glib
     gtk4
     libadwaita
-    gobject-introspection
     gst_all_1.gstreamer
     gst_all_1.gst-plugins-base
     gst_all_1.gst-plugins-good
@@ -48,9 +48,6 @@ python3Packages.buildPythonApplication rec {
     pygobject3
   ];
 
-  # Broken with gobject-introspection setup hook
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
   format = "other";
 
   postPatch = ''
diff --git a/pkgs/applications/audio/cozy/default.nix b/pkgs/applications/audio/cozy/default.nix
index 6398141c86d..8f7461683be 100644
--- a/pkgs/applications/audio/cozy/default.nix
+++ b/pkgs/applications/audio/cozy/default.nix
@@ -24,11 +24,6 @@ python3Packages.buildPythonApplication rec {
   pname = "cozy";
   version = "1.2.1";
 
-  # Temporary fix
-  # See https://github.com/NixOS/nixpkgs/issues/57029
-  # and https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   src = fetchFromGitHub {
     owner = "geigi";
     repo = pname;
diff --git a/pkgs/applications/audio/gpodder/default.nix b/pkgs/applications/audio/gpodder/default.nix
index a6164189c1d..d79aa713f08 100644
--- a/pkgs/applications/audio/gpodder/default.nix
+++ b/pkgs/applications/audio/gpodder/default.nix
@@ -27,17 +27,12 @@ python3Packages.buildPythonApplication rec {
     intltool
     wrapGAppsHook
     glibcLocales
+    gobject-introspection
   ];
 
-  # as of 2021-07, the gobject-introspection setup hook does not
-  # work with `strictDeps` enabled, thus for proper `wrapGAppsHook`
-  # it needs to be disabled explicitly. https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   buildInputs = [
     python3
     gtk3
-    gobject-introspection
     gnome.adwaita-icon-theme
   ];
 
diff --git a/pkgs/applications/audio/sonata/default.nix b/pkgs/applications/audio/sonata/default.nix
index 9eae394488e..78c17d09e0d 100644
--- a/pkgs/applications/audio/sonata/default.nix
+++ b/pkgs/applications/audio/sonata/default.nix
@@ -39,10 +39,6 @@ in buildPythonApplication rec {
     setuptools
   ];
 
-  # Otherwise the setup hook for gobject-introspection is not run:
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   postPatch = ''
     # Remove "Local MPD" tab which is not suitable for NixOS.
     sed -i '/localmpd/d' sonata/consts.py
diff --git a/pkgs/applications/audio/sublime-music/default.nix b/pkgs/applications/audio/sublime-music/default.nix
index d469c9689a5..5c64efce709 100644
--- a/pkgs/applications/audio/sublime-music/default.nix
+++ b/pkgs/applications/audio/sublime-music/default.nix
@@ -75,10 +75,6 @@ python3Packages.buildPythonApplication rec {
   ++ lib.optional serverSupport bottle
   ;
 
-  # hook for gobject-introspection doesn't like strictDeps
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   nativeCheckInputs = with python3Packages; [
     pytest
   ];
diff --git a/pkgs/applications/editors/rednotebook/default.nix b/pkgs/applications/editors/rednotebook/default.nix
index 2018e1d5e2a..abbfefce529 100644
--- a/pkgs/applications/editors/rednotebook/default.nix
+++ b/pkgs/applications/editors/rednotebook/default.nix
@@ -30,10 +30,6 @@ buildPythonApplication rec {
     "--suffix XDG_DATA_DIRS : $XDG_ICON_DIRS:$GSETTINGS_SCHEMAS_PATH"
   ];
 
-  # Until gobject-introspection in nativeBuildInputs is supported.
-  # https://github.com/NixOS/nixpkgs/issues/56943#issuecomment-472568643
-  strictDeps = false;
-
   meta = with lib; {
     homepage = "https://rednotebook.sourceforge.io/";
     changelog = "https://github.com/jendrikseipp/rednotebook/blob/v${version}/CHANGELOG.md";
diff --git a/pkgs/applications/graphics/curtail/default.nix b/pkgs/applications/graphics/curtail/default.nix
index 118703afc60..1d7df76c214 100644
--- a/pkgs/applications/graphics/curtail/default.nix
+++ b/pkgs/applications/graphics/curtail/default.nix
@@ -37,24 +37,30 @@ python3.pkgs.buildPythonApplication rec {
     meson
     ninja
     pkg-config
+    gobject-introspection
+  ];
+
+  buildInputs = [
+    appstream-glib
+    gettext
+    gtk3
   ];
 
   propagatedBuildInputs = [
-    appstream-glib
     python3.pkgs.pygobject3
-    gobject-introspection
-    gettext
   ];
 
-  # Currently still required for the gobject-introspection setup hook
-  strictDeps = false;
-
   preInstall = ''
     patchShebangs ../build-aux/meson/postinstall.py
   '';
 
-  postInstall = ''
-    wrapProgram $out/bin/curtail --prefix PATH : ${lib.makeBinPath [ jpegoptim libwebp optipng pngquant ]}
+  dontWrapGApps = true;
+
+  preFixup = ''
+    makeWrapperArgs+=(
+      "''${gappsWrapperArgs[@]}"
+      "--prefix" "PATH" ":" "${lib.makeBinPath [ jpegoptim libwebp optipng pngquant ]}"
+    )
   '';
 
   meta = with lib; {
diff --git a/pkgs/applications/graphics/mcomix/default.nix b/pkgs/applications/graphics/mcomix/default.nix
index fbc80d0da6d..2cec147fb30 100644
--- a/pkgs/applications/graphics/mcomix/default.nix
+++ b/pkgs/applications/graphics/mcomix/default.nix
@@ -25,17 +25,13 @@ python3.pkgs.buildPythonApplication rec {
     hash = "sha256-Nok4oqTezO84q9IDZvgi33ZeKfRL+tpg7QEDmp2ZZpU=";
   };
 
-  buildInputs = [ gobject-introspection gtk3 gdk-pixbuf ];
-  nativeBuildInputs = [ wrapGAppsHook ];
+  buildInputs = [ gtk3 gdk-pixbuf ];
+  nativeBuildInputs = [ wrapGAppsHook gobject-introspection ];
   propagatedBuildInputs = (with python3.pkgs; [ pillow pygobject3 pycairo ]);
 
   # Tests are broken
   doCheck = false;
 
-  # Correct wrapper behavior, see https://github.com/NixOS/nixpkgs/issues/56943
-  # until https://github.com/NixOS/nixpkgs/pull/102613
-  strictDeps = false;
-
   # prevent double wrapping
   dontWrapGApps = true;
 
diff --git a/pkgs/applications/graphics/pick-colour-picker/default.nix b/pkgs/applications/graphics/pick-colour-picker/default.nix
index 0d3a86663b3..774a8b19dd3 100644
--- a/pkgs/applications/graphics/pick-colour-picker/default.nix
+++ b/pkgs/applications/graphics/pick-colour-picker/default.nix
@@ -37,10 +37,6 @@ buildPythonPackage rec {
     gtk3
   ];
 
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  # this must be false, otherwise the gobject-introspection hook doesn't run
-  strictDeps = false;
-
   preDistPhases = [ "fixupIconPath" ];
 
   fixupIconPath = ''
diff --git a/pkgs/applications/misc/gnome-secrets/default.nix b/pkgs/applications/misc/gnome-secrets/default.nix
index 1b8a7e706dd..676a19641bd 100644
--- a/pkgs/applications/misc/gnome-secrets/default.nix
+++ b/pkgs/applications/misc/gnome-secrets/default.nix
@@ -18,7 +18,6 @@ python3Packages.buildPythonApplication rec {
   pname = "gnome-secrets";
   version = "7.2";
   format = "other";
-  strictDeps = false; # https://github.com/NixOS/nixpkgs/issues/56943
 
   src = fetchFromGitLab {
     domain = "gitlab.gnome.org";
diff --git a/pkgs/applications/misc/hamster/default.nix b/pkgs/applications/misc/hamster/default.nix
index dbf7e1aee74..925d246ba84 100644
--- a/pkgs/applications/misc/hamster/default.nix
+++ b/pkgs/applications/misc/hamster/default.nix
@@ -1,4 +1,4 @@
-{ lib, fetchFromGitHub, python3Packages, intltool, glib, itstool
+{ lib, fetchFromGitHub, python3Packages, intltool, glib, itstool, gtk3
 , wrapGAppsHook, gobject-introspection, pango, gdk-pixbuf, atk, wafHook }:
 
 python3Packages.buildPythonApplication rec {
@@ -28,6 +28,7 @@ python3Packages.buildPythonApplication rec {
     pango
     gdk-pixbuf
     atk
+    gtk3
   ];
 
   propagatedBuildInputs = with python3Packages; [
@@ -37,10 +38,6 @@ python3Packages.buildPythonApplication rec {
     dbus-python
   ];
 
-  # Setup hooks have trouble with strict deps.
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   dontWrapGApps = true;
 
   # Arguments to be passed to `makeWrapper`, only used by buildPython*
diff --git a/pkgs/applications/misc/kupfer/default.nix b/pkgs/applications/misc/kupfer/default.nix
index 47e310fb765..fbb33c7e096 100644
--- a/pkgs/applications/misc/kupfer/default.nix
+++ b/pkgs/applications/misc/kupfer/default.nix
@@ -11,6 +11,8 @@
 , shared-mime-info
 , wrapGAppsHook
 , wafHook
+, bash
+, dbus
 }:
 
 with python3Packages;
@@ -33,14 +35,12 @@ buildPythonApplication rec {
     itstool            # for help pages
     desktop-file-utils # for update-desktop-database
     shared-mime-info   # for update-mime-info
+    docutils # for rst2man
+    dbus # for detection of dbus-send during build
   ];
-  buildInputs = [ docutils libwnck keybinder3 ];
+  buildInputs = [ libwnck keybinder3 bash ];
   propagatedBuildInputs = [ pygobject3 gtk3 pyxdg dbus-python pycairo ];
 
-  # without strictDeps kupfer fails to build: Could not find the python module 'gi.repository.Gtk'
-  # see https://github.com/NixOS/nixpkgs/issues/56943 for details
-  strictDeps = false;
-
   postInstall = ''
     gappsWrapperArgs+=(
       "--prefix" "PYTHONPATH" : "${makePythonPath propagatedBuildInputs}"
diff --git a/pkgs/applications/misc/lutris/default.nix b/pkgs/applications/misc/lutris/default.nix
index d476024553b..35dbf1fcb44 100644
--- a/pkgs/applications/misc/lutris/default.nix
+++ b/pkgs/applications/misc/lutris/default.nix
@@ -84,13 +84,12 @@ buildPythonApplication rec {
     sha256 = "sha256-rsiXm7L/M85ot6NrTyy//lMRFlLPJYve9y6Erg9Ugxg=";
   };
 
-  nativeBuildInputs = [ wrapGAppsHook ];
+  nativeBuildInputs = [ wrapGAppsHook gobject-introspection ];
   buildInputs = [
     atk
     gdk-pixbuf
     glib-networking
     gnome-desktop
-    gobject-introspection
     gtk3
     libnotify
     pango
@@ -139,9 +138,6 @@ buildPythonApplication rec {
     "--prefix PATH : ${lib.makeBinPath requiredTools}"
     "\${gappsWrapperArgs[@]}"
   ];
-  # needed for glib-schemas to work correctly (will crash on dialogues otherwise)
-  # see https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
 
   meta = with lib; {
     homepage = "https://lutris.net";
diff --git a/pkgs/applications/misc/minigalaxy/default.nix b/pkgs/applications/misc/minigalaxy/default.nix
index 743c92407e7..4dffe9e08eb 100644
--- a/pkgs/applications/misc/minigalaxy/default.nix
+++ b/pkgs/applications/misc/minigalaxy/default.nix
@@ -31,18 +31,14 @@ python3Packages.buildPythonApplication rec {
     runHook postCheck
   '';
 
-  # Cannot find GSettings schemas when opening settings,
-  # probably https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   nativeBuildInputs = [
     gettext
     wrapGAppsHook
+    gobject-introspection
   ];
 
   buildInputs = [
     glib-networking
-    gobject-introspection
     gtk3
   ];
 
@@ -64,6 +60,7 @@ python3Packages.buildPythonApplication rec {
   ];
 
   # Run Linux games using the Steam Runtime by using steam-run in the wrapper
+  # FIXME: not working with makeBinaryWrapper
   postFixup = ''
     sed -e 's#exec -a "$0"#exec -a "$0" ${steam-run}/bin/steam-run#' -i $out/bin/minigalaxy
   '';
diff --git a/pkgs/applications/misc/onboard/default.nix b/pkgs/applications/misc/onboard/default.nix
index 472af0caf48..9d88d6331c1 100644
--- a/pkgs/applications/misc/onboard/default.nix
+++ b/pkgs/applications/misc/onboard/default.nix
@@ -108,9 +108,6 @@ python3.pkgs.buildPythonApplication rec {
     python3.pkgs.nose
   ];
 
-  # Temporary fix, see https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   doCheck = false;
 
   preBuild = ''
diff --git a/pkgs/applications/misc/printrun/default.nix b/pkgs/applications/misc/printrun/default.nix
index 7ae8662e2c1..546c0544cff 100644
--- a/pkgs/applications/misc/printrun/default.nix
+++ b/pkgs/applications/misc/printrun/default.nix
@@ -32,8 +32,6 @@ python3Packages.buildPythonApplication rec {
   '';
 
   dontWrapGApps = true;
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
 
   preFixup = ''
     makeWrapperArgs+=("''${gappsWrapperArgs[@]}")
diff --git a/pkgs/applications/misc/wike/default.nix b/pkgs/applications/misc/wike/default.nix
index c3e5a505722..00cd8dcf051 100644
--- a/pkgs/applications/misc/wike/default.nix
+++ b/pkgs/applications/misc/wike/default.nix
@@ -12,7 +12,6 @@ python3.pkgs.buildPythonApplication rec {
   pname = "wike";
   version = "1.7.1";
   format = "other";
-  strictDeps = false; # https://github.com/NixOS/nixpkgs/issues/56943
 
   src = fetchFromGitHub {
     owner = "hugolabe";
diff --git a/pkgs/applications/networking/feedreaders/gnome-feeds/default.nix b/pkgs/applications/networking/feedreaders/gnome-feeds/default.nix
index f80be45ebd1..7563e8c22d7 100644
--- a/pkgs/applications/networking/feedreaders/gnome-feeds/default.nix
+++ b/pkgs/applications/networking/feedreaders/gnome-feeds/default.nix
@@ -66,9 +66,6 @@ python3.pkgs.buildPythonApplication rec {
     requests
   ];
 
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   dontWrapGApps = true;
 
   preFixup = ''
diff --git a/pkgs/applications/networking/giara/default.nix b/pkgs/applications/networking/giara/default.nix
index 60c2ad8262c..3e10a61a63f 100644
--- a/pkgs/applications/networking/giara/default.nix
+++ b/pkgs/applications/networking/giara/default.nix
@@ -64,9 +64,6 @@ python3.pkgs.buildPythonApplication rec {
       --replace "gtk-update-icon-cache" "gtk4-update-icon-cache"
   '';
 
-  # Fix setup-hooks https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   meta = with lib; {
     description = "A Reddit app, built with Python, GTK and Handy; Created with mobile Linux in mind";
     maintainers = with maintainers; [ dasj19 ];
diff --git a/pkgs/applications/networking/mailreaders/bubblemail/default.nix b/pkgs/applications/networking/mailreaders/bubblemail/default.nix
index 61276220756..bd5783a5c65 100644
--- a/pkgs/applications/networking/mailreaders/bubblemail/default.nix
+++ b/pkgs/applications/networking/mailreaders/bubblemail/default.nix
@@ -13,6 +13,7 @@
 , glib
 , gobject-introspection
 , folks
+, bash
 }:
 
 python3Packages.buildPythonApplication rec {
@@ -39,6 +40,7 @@ python3Packages.buildPythonApplication rec {
     libsecret
     gnome-online-accounts
     folks
+    bash
   ];
 
   nativeBuildInputs = [
@@ -59,9 +61,6 @@ python3Packages.buildPythonApplication rec {
   # See https://nixos.org/nixpkgs/manual/#ssec-gnome-common-issues-double-wrapped
   dontWrapGApps = true;
 
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   preFixup = ''
     makeWrapperArgs+=("''${gappsWrapperArgs[@]}")
   '';
diff --git a/pkgs/applications/networking/protonvpn-gui/default.nix b/pkgs/applications/networking/protonvpn-gui/default.nix
index 98f7ac541a7..14844161d18 100644
--- a/pkgs/applications/networking/protonvpn-gui/default.nix
+++ b/pkgs/applications/networking/protonvpn-gui/default.nix
@@ -41,8 +41,6 @@ buildPythonApplication rec {
   ];
 
   buildInputs = [
-    # To avoid enabling strictDeps = false (#56943)
-    gobject-introspection
     librsvg
     pango
     webkitgtk
diff --git a/pkgs/applications/office/gtg/default.nix b/pkgs/applications/office/gtg/default.nix
index 8165cc381c1..44aaa6c7146 100644
--- a/pkgs/applications/office/gtg/default.nix
+++ b/pkgs/applications/office/gtg/default.nix
@@ -67,7 +67,6 @@ python3Packages.buildPythonApplication rec {
   '';
 
   format = "other";
-  strictDeps = false; # gobject-introspection does not run with strictDeps (https://github.com/NixOS/nixpkgs/issues/56943)
 
   checkPhase = "xvfb-run pytest ../tests/";
 
diff --git a/pkgs/applications/office/zim/default.nix b/pkgs/applications/office/zim/default.nix
index 73c94f7339c..c20c9449ae8 100644
--- a/pkgs/applications/office/zim/default.nix
+++ b/pkgs/applications/office/zim/default.nix
@@ -14,9 +14,8 @@ python3Packages.buildPythonApplication rec {
     sha256 = "sha256-iOF11/fhQYlvnpWJidJS1yJVavF7xLxvBl59VCh9A4U=";
   };
 
-  buildInputs = [ gtk3 gobject-introspection gnome.adwaita-icon-theme ];
+  buildInputs = [ gtk3 gnome.adwaita-icon-theme ];
   propagatedBuildInputs = with python3Packages; [ pyxdg pygobject3 ];
-  # see https://github.com/NixOS/nixpkgs/issues/56943#issuecomment-1131643663
   nativeBuildInputs = [ gobject-introspection wrapGAppsHook ];
 
   dontWrapGApps = true;
diff --git a/pkgs/applications/science/misc/bada-bib/default.nix b/pkgs/applications/science/misc/bada-bib/default.nix
index 76495f5cae1..7ad542402b5 100644
--- a/pkgs/applications/science/misc/bada-bib/default.nix
+++ b/pkgs/applications/science/misc/bada-bib/default.nix
@@ -22,7 +22,6 @@ python3Packages.buildPythonApplication rec {
   pname = "bada-bib";
   version = "0.8.0";
   format = "other";
-  strictDeps = false; # https://github.com/NixOS/nixpkgs/issues/56943
 
   src = fetchFromGitHub {
     owner = "RogerCrocker";
diff --git a/pkgs/applications/terminal-emulators/guake/default.nix b/pkgs/applications/terminal-emulators/guake/default.nix
index ee28a250478..d030c7add96 100644
--- a/pkgs/applications/terminal-emulators/guake/default.nix
+++ b/pkgs/applications/terminal-emulators/guake/default.nix
@@ -26,11 +26,6 @@ python3.pkgs.buildPythonApplication rec {
     sha256 = "sha256-BW13fBH26UqMPMjV8JC4QkpgzyoPfCpAfSkJD68uOZU=";
   };
 
-  # Strict deps breaks guake
-  # See https://github.com/NixOS/nixpkgs/issues/59930
-  # and https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   nativeBuildInputs = [
     gobject-introspection
     wrapGAppsHook
diff --git a/pkgs/applications/version-management/meld/default.nix b/pkgs/applications/version-management/meld/default.nix
index 121a0cdf773..224efe8c1ac 100644
--- a/pkgs/applications/version-management/meld/default.nix
+++ b/pkgs/applications/version-management/meld/default.nix
@@ -52,10 +52,6 @@ python3.pkgs.buildPythonApplication rec {
     pycairo
   ];
 
-  # gobject-introspection and some other similar setup hooks do not currently work with strictDeps.
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   postPatch = ''
     patchShebangs meson_shebang_normalisation.py
   '';
diff --git a/pkgs/applications/video/devede/default.nix b/pkgs/applications/video/devede/default.nix
index e8fa11c9147..800edd4792c 100644
--- a/pkgs/applications/video/devede/default.nix
+++ b/pkgs/applications/video/devede/default.nix
@@ -15,17 +15,8 @@ in buildPythonApplication rec {
     sha256 = "1xb7acjphvn4ya8fgjsvag5gzi9a6c2famfl0ffr8nhb9y8ig9mg";
   };
 
-  # Temporary fix
-  # See https://github.com/NixOS/nixpkgs/issues/61578
-  # and https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   nativeBuildInputs = [
     gettext wrapGAppsHook
-
-    # Temporary fix
-    # See https://github.com/NixOS/nixpkgs/issues/61578
-    # and https://github.com/NixOS/nixpkgs/issues/56943
     gobject-introspection
   ];
 
diff --git a/pkgs/applications/video/kazam/default.nix b/pkgs/applications/video/kazam/default.nix
index 4ba0fe98df0..e44949f54ba 100644
--- a/pkgs/applications/video/kazam/default.nix
+++ b/pkgs/applications/video/kazam/default.nix
@@ -40,9 +40,6 @@ python3Packages.buildPythonApplication rec {
 
   propagatedBuildInputs = with python3Packages; [ pygobject3 pyxdg pycairo dbus-python xlib ];
 
-  # workaround https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   patches = [
     # Fix paths
     (substituteAll {
diff --git a/pkgs/applications/video/pitivi/default.nix b/pkgs/applications/video/pitivi/default.nix
index 5406b7dfa8a..7e6f89855ed 100644
--- a/pkgs/applications/video/pitivi/default.nix
+++ b/pkgs/applications/video/pitivi/default.nix
@@ -44,10 +44,10 @@ python3.pkgs.buildPythonApplication rec {
     itstool
     python3
     wrapGAppsHook
+    gobject-introspection
   ];
 
   buildInputs = [
-    gobject-introspection
     gtk3
     libpeas
     librsvg
@@ -78,12 +78,6 @@ python3.pkgs.buildPythonApplication rec {
     patchShebangs ./getenvvar.py
   '';
 
-  # Fixes error
-  #     Couldn’t recognize the image file format for file ".../share/pitivi/pixmaps/asset-proxied.svg"
-  # at startup, see https://github.com/NixOS/nixpkgs/issues/56943
-  # and https://github.com/NixOS/nixpkgs/issues/89691#issuecomment-714398705.
-  strictDeps = false;
-
   passthru = {
     updateScript = gnome.updateScript {
       packageName = "pitivi";
diff --git a/pkgs/applications/virtualization/virt-manager/default.nix b/pkgs/applications/virtualization/virt-manager/default.nix
index e5d5a1fbfe7..1a9fe490af8 100644
--- a/pkgs/applications/virtualization/virt-manager/default.nix
+++ b/pkgs/applications/virtualization/virt-manager/default.nix
@@ -26,7 +26,6 @@ python3.pkgs.buildPythonApplication rec {
     wrapGAppsHook
     libvirt-glib vte dconf gtk-vnc gnome.adwaita-icon-theme avahi
     gsettings-desktop-schemas libosinfo gtksourceview4
-    gobject-introspection # Temporary fix, see https://github.com/NixOS/nixpkgs/issues/56943
   ] ++ lib.optional spiceSupport spice-gtk;
 
   propagatedBuildInputs = with python3.pkgs; [
diff --git a/pkgs/build-support/setup-hooks/wrap-gapps-hook/default.nix b/pkgs/build-support/setup-hooks/wrap-gapps-hook/default.nix
index 99633a3c7c9..3c5199be313 100644
--- a/pkgs/build-support/setup-hooks/wrap-gapps-hook/default.nix
+++ b/pkgs/build-support/setup-hooks/wrap-gapps-hook/default.nix
@@ -17,6 +17,24 @@ makeSetupHook {
   propagatedBuildInputs = [
     # We use the wrapProgram function.
     makeWrapper
+  ] ++ lib.optionals isGraphical [
+    # TODO: remove this, packages should depend on GTK explicitly.
+    gtk3
+
+    librsvg
+  ];
+
+  # depsTargetTargetPropagated will essentially be buildInputs when wrapGAppsHook is placed into nativeBuildInputs
+  # the librsvg and gtk3 above should be removed but kept to not break anything that implicitly depended on its binaries
+  depsTargetTargetPropagated = assert (lib.assertMsg (!targetPackages ? raw) "wrapGAppsHook must be in nativeBuildInputs"); lib.optionals isGraphical [
+    # librsvg provides a module for gdk-pixbuf to allow rendering
+    # SVG icons. Most icon themes are SVG-based and so are some
+    # graphics in GTK (e.g. cross for closing window in window title bar)
+    # so it is pretty much required for applications using GTK.
+    librsvg
+
+    # TODO: remove this, packages should depend on GTK explicitly.
+    gtk3
   ] ++ lib.optionals (!stdenv.isDarwin) [
     # It is highly probable that a program will use GSettings,
     # at minimum through GTK file chooser dialogue.
@@ -26,22 +44,6 @@ makeSetupHook {
     # Unfortunately, it also requires the user to have dconf
     # D-Bus service enabled globally (e.g. through a NixOS module).
     dconf.lib
-
-  ] ++ lib.optionals isGraphical [
-    # TODO: remove this, packages should depend on GTK explicitly.
-    gtk3
-
-    librsvg
-  ];
-
-  # depsTargetTargetPropagated will essentially be buildInputs when wrapGAppsHook is placed into nativeBuildInputs
-  # the librsvg above should be removed but kept to not break anything that implicitly depended on its binaries
-  depsTargetTargetPropagated = assert (lib.assertMsg (!targetPackages ? raw) "wrapGAppsHook must be in nativeBuildInputs"); lib.optionals isGraphical [
-    # librsvg provides a module for gdk-pixbuf to allow rendering
-    # SVG icons. Most icon themes are SVG-based and so are some
-    # graphics in GTK (e.g. cross for closing window in window title bar)
-    # so it is pretty much required for applications using GTK.
-    librsvg
   ];
   passthru = {
     tests = let
@@ -56,6 +58,7 @@ makeSetupHook {
 
         src = sample-project;
 
+        strictDeps = true;
         nativeBuildInputs = [ wrapGAppsHook ];
 
         installFlags = [ "bin-foo" "libexec-bar" ];
@@ -86,6 +89,8 @@ makeSetupHook {
 
         src = sample-project;
 
+        strictDeps = true;
+
         installFlags = [ "typelib-Mahjong" ];
       };
 
@@ -95,6 +100,7 @@ makeSetupHook {
 
         src = sample-project;
 
+        strictDeps = true;
         nativeBuildInputs = [
           gobject-introspection
           wrapGAppsHook
@@ -126,6 +132,8 @@ makeSetupHook {
 
         src = sample-project;
 
+        strictDeps = true;
+
         makeFlags = [
           "LIBDIR=${placeholder "lib"}/lib"
         ];
@@ -139,6 +147,7 @@ makeSetupHook {
 
         src = sample-project;
 
+        strictDeps = true;
         nativeBuildInputs = [
           gobject-introspection
           wrapGAppsHook
@@ -169,6 +178,7 @@ makeSetupHook {
 
         src = sample-project;
 
+        strictDeps = true;
         nativeBuildInputs = [
           gobject-introspection
           wrapGAppsHook
diff --git a/pkgs/desktops/gnome/apps/accerciser/default.nix b/pkgs/desktops/gnome/apps/accerciser/default.nix
index 7d4f5969d0d..d21d1c20061 100644
--- a/pkgs/desktops/gnome/apps/accerciser/default.nix
+++ b/pkgs/desktops/gnome/apps/accerciser/default.nix
@@ -13,6 +13,7 @@
 , gettext
 , libwnck
 , adwaita-icon-theme
+, librsvg
 }:
 
 python3.pkgs.buildPythonApplication rec {
@@ -41,6 +42,7 @@ python3.pkgs.buildPythonApplication rec {
     at-spi2-core
     gtk3
     libwnck
+    librsvg
   ];
 
   propagatedBuildInputs = with python3.pkgs; [
@@ -52,10 +54,6 @@ python3.pkgs.buildPythonApplication rec {
     xlib
   ];
 
-  # Strict deps breaks accerciser
-  # and https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   passthru = {
     updateScript = gnome.updateScript {
       packageName = "accerciser";
diff --git a/pkgs/desktops/gnome/misc/gnome-tweaks/default.nix b/pkgs/desktops/gnome/misc/gnome-tweaks/default.nix
index efad1cc14db..dbf3dbd9be3 100644
--- a/pkgs/desktops/gnome/misc/gnome-tweaks/default.nix
+++ b/pkgs/desktops/gnome/misc/gnome-tweaks/default.nix
@@ -22,7 +22,6 @@ python3Packages.buildPythonApplication rec {
   pname = "gnome-tweaks";
   version = "42.beta";
   format = "other";
-  strictDeps = false; # https://github.com/NixOS/nixpkgs/issues/56943
 
   src = fetchurl {
     url = "mirror://gnome/sources/${pname}/${lib.versions.major version}/${pname}-${version}.tar.xz";
diff --git a/pkgs/desktops/xfce/applications/catfish/default.nix b/pkgs/desktops/xfce/applications/catfish/default.nix
index f78f420cabc..2f16352f8ca 100644
--- a/pkgs/desktops/xfce/applications/catfish/default.nix
+++ b/pkgs/desktops/xfce/applications/catfish/default.nix
@@ -41,7 +41,6 @@ python3Packages.buildPythonApplication rec {
     python3Packages.pyxdg
     python3Packages.ptyprocess
     python3Packages.pycairo
-    gobject-introspection # Temporary fix, see https://github.com/NixOS/nixpkgs/issues/56943
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/libraries/librsvg/default.nix b/pkgs/development/libraries/librsvg/default.nix
index a78bf86a18c..57ed620fbf8 100644
--- a/pkgs/development/libraries/librsvg/default.nix
+++ b/pkgs/development/libraries/librsvg/default.nix
@@ -20,7 +20,9 @@
 , python3Packages
 , gnome
 , vala
-, withIntrospection ? stdenv.hostPlatform == stdenv.buildPlatform
+, writeScript
+, withIntrospection ? stdenv.hostPlatform.emulatorAvailable buildPackages
+, buildPackages
 , gobject-introspection
 , _experimental-update-script-combinators
 , common-updater-scripts
@@ -71,6 +73,7 @@ stdenv.mkDerivation rec {
     bzip2
     pango
     libintl
+    vala # for share/vala/Makefile.vapigen
   ] ++ lib.optionals stdenv.isDarwin [
     ApplicationServices
     Foundation
@@ -93,6 +96,15 @@ stdenv.mkDerivation rec {
 
   doCheck = false; # all tests fail on libtool-generated rsvg-convert not being able to find coreutils
 
+  GDK_PIXBUF_QUERYLOADERS = writeScript "gdk-pixbuf-loader-loaders-wrapped" ''
+    ${lib.optionalString (stdenv.hostPlatform.emulatorAvailable buildPackages) (stdenv.hostPlatform.emulator buildPackages)} ${lib.getDev gdk-pixbuf}/bin/gdk-pixbuf-query-loaders
+  '';
+
+  preConfigure = ''
+    PKG_CONFIG_VAPIGEN_VAPIGEN="$(type -p vapigen)"
+    export PKG_CONFIG_VAPIGEN_VAPIGEN
+  '';
+
   # It wants to add loaders and update the loaders.cache in gdk-pixbuf
   # Patching the Makefiles to it creates rsvg specific loaders and the
   # relevant loader.cache here.
@@ -114,10 +126,14 @@ stdenv.mkDerivation rec {
 
     # 'error: linker `cc` not found' when cross-compiling
     export RUSTFLAGS="-Clinker=$CC"
+  '' + lib.optionalString ((stdenv.buildPlatform != stdenv.hostPlatform) && (stdenv.hostPlatform.emulatorAvailable buildPackages)) ''
+    # the replacement is the native conditional
+    substituteInPlace gdk-pixbuf-loader/Makefile \
+      --replace 'RUN_QUERY_LOADER_TEST = false' 'RUN_QUERY_LOADER_TEST = test -z "$(DESTDIR)"' \
   '';
 
   # Not generated when cross compiling.
-  postInstall = lib.optionalString (stdenv.hostPlatform == stdenv.buildPlatform) ''
+  postInstall = lib.optionalString (stdenv.hostPlatform.emulatorAvailable buildPackages) ''
     # Merge gdkpixbuf and librsvg loaders
     cat ${lib.getLib gdk-pixbuf}/lib/gdk-pixbuf-2.0/2.10.0/loaders.cache $GDK_PIXBUF/loaders.cache > $GDK_PIXBUF/loaders.cache.tmp
     mv $GDK_PIXBUF/loaders.cache.tmp $GDK_PIXBUF/loaders.cache
diff --git a/pkgs/development/python-modules/dogtail/default.nix b/pkgs/development/python-modules/dogtail/default.nix
index cc4430ddb39..2f8a02dc3ec 100644
--- a/pkgs/development/python-modules/dogtail/default.nix
+++ b/pkgs/development/python-modules/dogtail/default.nix
@@ -37,7 +37,6 @@ buildPythonPackage {
 
   nativeBuildInputs = [ gobject-introspection dbus xvfb-run wrapGAppsHook ]; # for setup hooks
   propagatedBuildInputs = [ at-spi2-core gtk3 pygobject3 pyatspi pycairo ];
-  strictDeps = false; # issue 56943
 
   checkPhase = ''
     runHook preCheck
@@ -50,6 +49,12 @@ buildPythonPackage {
     runHook postCheck
   '';
 
+  dontWrapGApps = true;
+
+  preFixup = ''
+    makeWrapperArgs+=("''${gappsWrapperArgs[@]}")
+  '';
+
   # TODO: Tests require accessibility
   doCheck = false;
 
diff --git a/pkgs/development/tools/cambalache/default.nix b/pkgs/development/tools/cambalache/default.nix
index e2e7157425b..43a5778ff95 100644
--- a/pkgs/development/tools/cambalache/default.nix
+++ b/pkgs/development/tools/cambalache/default.nix
@@ -57,15 +57,16 @@ python3.pkgs.buildPythonApplication rec {
     libhandy
   ];
 
-  # Not compatible with gobject-introspection setup hooks.
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   # Prevent double wrapping.
   dontWrapGApps = true;
 
   postPatch = ''
     patchShebangs postinstall.py
+    # those programs are used at runtime not build time
+    # https://gitlab.gnome.org/jpu/cambalache/-/blob/main/meson.build#L79-80
+    substituteInPlace ./meson.build \
+      --replace "find_program('broadwayd', required: true)" "" \
+      --replace "find_program('gtk4-broadwayd', required: true)" ""
   '';
 
   preFixup = ''
diff --git a/pkgs/development/tools/misc/d-feet/default.nix b/pkgs/development/tools/misc/d-feet/default.nix
index d105dd61665..c59ed440b7c 100644
--- a/pkgs/development/tools/misc/d-feet/default.nix
+++ b/pkgs/development/tools/misc/d-feet/default.nix
@@ -63,10 +63,6 @@ python3.pkgs.buildPythonApplication rec {
     "-Dtests=false" # needs dbus
   ];
 
-  # Temporary fix
-  # See https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   postPatch = ''
     chmod +x meson_post_install.py
     patchShebangs meson_post_install.py
diff --git a/pkgs/misc/drivers/sc-controller/default.nix b/pkgs/misc/drivers/sc-controller/default.nix
index 0aeb5f2e963..11663d5d4c4 100644
--- a/pkgs/misc/drivers/sc-controller/default.nix
+++ b/pkgs/misc/drivers/sc-controller/default.nix
@@ -18,12 +18,9 @@ buildPythonApplication rec {
     sha256 = "sha256-ym5fkOTRhibBaUqT0+p/jyqqKOVsyMz5INgfkoz0IJA=";
   };
 
-  # see https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
+  nativeBuildInputs = [ wrapGAppsHook gobject-introspection ];
 
-  nativeBuildInputs = [ wrapGAppsHook ];
-
-  buildInputs = [ gtk3 gobject-introspection libappindicator-gtk3 librsvg ];
+  buildInputs = [ gtk3 libappindicator-gtk3 librsvg ];
 
   propagatedBuildInputs = [ evdev pygobject3 pylibacl vdf ];
 
diff --git a/pkgs/misc/solfege/default.nix b/pkgs/misc/solfege/default.nix
index 121933f69e9..64ddfae7b32 100644
--- a/pkgs/misc/solfege/default.nix
+++ b/pkgs/misc/solfege/default.nix
@@ -35,13 +35,11 @@ buildPythonApplication rec {
     texinfo
     txt2man
 
-    # https://github.com/NixOS/nixpkgs/issues/56943#issuecomment-1131643663
     gobject-introspection
     wrapGAppsHook
   ];
 
   buildInputs = [
-    gobject-introspection
     gtk3
     librsvg
   ];
diff --git a/pkgs/os-specific/linux/piper/default.nix b/pkgs/os-specific/linux/piper/default.nix
index 293425897e9..39b0eaf5325 100644
--- a/pkgs/os-specific/linux/piper/default.nix
+++ b/pkgs/os-specific/linux/piper/default.nix
@@ -19,9 +19,7 @@ python3.pkgs.buildPythonApplication rec {
   buildInputs = [
     gtk3 glib gnome.adwaita-icon-theme python3 librsvg
   ];
-  propagatedBuildInputs = with python3.pkgs; [ lxml evdev pygobject3 ] ++ [
-    gobject-introspection # fixes https://github.com/NixOS/nixpkgs/issues/56943 for now
-  ];
+  propagatedBuildInputs = with python3.pkgs; [ lxml evdev pygobject3 ];
 
   mesonFlags = [
     "-Druntime-dependency-checks=false"
diff --git a/pkgs/tools/X11/arandr/default.nix b/pkgs/tools/X11/arandr/default.nix
index 0d8303c0df4..6c4c89e8888 100644
--- a/pkgs/tools/X11/arandr/default.nix
+++ b/pkgs/tools/X11/arandr/default.nix
@@ -27,10 +27,6 @@ buildPythonApplication rec {
   # no tests
   doCheck = false;
 
-  # hook for gobject-introspection doesn't like strictDeps
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   buildInputs = [ docutils gsettings-desktop-schemas gtk3 ];
   nativeBuildInputs = [ gobject-introspection wrapGAppsHook ];
   propagatedBuildInputs = [ xrandr pygobject3 ];
diff --git a/pkgs/tools/audio/beets/common.nix b/pkgs/tools/audio/beets/common.nix
index 4cfef4657e3..b3eefbf9cba 100644
--- a/pkgs/tools/audio/beets/common.nix
+++ b/pkgs/tools/audio/beets/common.nix
@@ -61,7 +61,6 @@ python3Packages.buildPythonApplication rec {
 
   propagatedBuildInputs = with python3Packages; [
     confuse
-    gobject-introspection
     gst-python
     jellyfish
     mediafile
@@ -74,7 +73,6 @@ python3Packages.buildPythonApplication rec {
     unidecode
   ] ++ (concatMap (p: p.propagatedBuildInputs) (attrValues enabledPlugins));
 
-  # see: https://github.com/NixOS/nixpkgs/issues/56943#issuecomment-1131643663
   nativeBuildInputs = [
     gobject-introspection
     sphinxHook
diff --git a/pkgs/tools/audio/mpdris2/default.nix b/pkgs/tools/audio/mpdris2/default.nix
index a367da9828e..fd8618d6243 100644
--- a/pkgs/tools/audio/mpdris2/default.nix
+++ b/pkgs/tools/audio/mpdris2/default.nix
@@ -13,7 +13,6 @@ python3.pkgs.buildPythonApplication rec {
   pname = "mpDris2";
   version = "0.9.1";
   format = "other";
-  strictDeps = false; # https://github.com/NixOS/nixpkgs/issues/56943
 
   src = fetchFromGitHub {
     owner = "eonpatapon";
diff --git a/pkgs/tools/inputmethods/input-remapper/default.nix b/pkgs/tools/inputmethods/input-remapper/default.nix
index c6941607683..092901e08c3 100644
--- a/pkgs/tools/inputmethods/input-remapper/default.nix
+++ b/pkgs/tools/inputmethods/input-remapper/default.nix
@@ -45,11 +45,6 @@ in
     hash = "sha256-KPQLgXSonuOgphagYN2JN+CMIpmjTIPUTCqOPDk0UYU=";
   };
 
-  # Fixes error
-  # Couldn’t recognize the image file format for file "*.svg"
-  # at startup, see https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   postPatch = ''
     # fix FHS paths
     substituteInPlace inputremapper/configs/data.py \
diff --git a/pkgs/tools/misc/gaphor/default.nix b/pkgs/tools/misc/gaphor/default.nix
index 95d9f911273..a97b887f1ca 100644
--- a/pkgs/tools/misc/gaphor/default.nix
+++ b/pkgs/tools/misc/gaphor/default.nix
@@ -37,11 +37,7 @@ buildPythonApplication rec {
     wrapGAppsHook
   ];
 
-  # Setting gobject-introspection on booth nativeBuildInputs and
-  # buildInputs because of #56943. This recognizes pango, avoiding
-  # a "ValueError: Namespace PangoCairo not available".
   buildInputs = [
-    gobject-introspection
     gtksourceview4
     pango
   ];
diff --git a/pkgs/tools/misc/trackma/default.nix b/pkgs/tools/misc/trackma/default.nix
index e3d6322b85e..855585dde3f 100644
--- a/pkgs/tools/misc/trackma/default.nix
+++ b/pkgs/tools/misc/trackma/default.nix
@@ -35,10 +35,10 @@ python3.pkgs.buildPythonApplication rec {
   };
 
   nativeBuildInputs = [ copyDesktopItems ]
-    ++ lib.optionals withGTK [ wrapGAppsHook ]
+    ++ lib.optionals withGTK [ wrapGAppsHook gobject-introspection ]
     ++ lib.optionals withQT [ qt5.wrapQtAppsHook ];
 
-  buildInputs = lib.optionals withGTK [ glib gobject-introspection gtk3 ];
+  buildInputs = lib.optionals withGTK [ glib gtk3 ];
 
   propagatedBuildInputs = with python3.pkgs; ([ urllib3 ]
     ++ lib.optionals withQT [ pyqt5 ]
@@ -47,9 +47,6 @@ python3.pkgs.buildPythonApplication rec {
     ++ lib.optionals stdenv.isLinux [ dbus-python pygobject3 pyinotify ]
     ++ lib.optionals (withGTK || withQT) [ pillow ]);
 
-  # broken with gobject-introspection setup hook, see https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   dontWrapQtApps = true;
   dontWrapGApps = true;
 
diff --git a/pkgs/tools/security/gnome-keysign/default.nix b/pkgs/tools/security/gnome-keysign/default.nix
index 50a1ff98d14..f5157fc9e41 100644
--- a/pkgs/tools/security/gnome-keysign/default.nix
+++ b/pkgs/tools/security/gnome-keysign/default.nix
@@ -67,9 +67,6 @@ python3.pkgs.buildPythonApplication rec {
     twisted
   ];
 
-  # https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   # bunch of linting
   doCheck = false;
 
diff --git a/pkgs/tools/security/xsser/default.nix b/pkgs/tools/security/xsser/default.nix
index 5028b3c7721..6c75f2e733f 100644
--- a/pkgs/tools/security/xsser/default.nix
+++ b/pkgs/tools/security/xsser/default.nix
@@ -22,10 +22,6 @@ buildPythonApplication rec {
     substituteInPlace setup.py --replace /usr/share share
   '';
 
-  # Temporary fix
-  # See https://github.com/NixOS/nixpkgs/issues/56943
-  strictDeps = false;
-
   nativeBuildInputs = [ wrapGAppsHook gobject-introspection ];
 
   buildInputs = [