diff --git a/pkgs/development/libraries/libtiff/0001-Disable-OpenGL.patch b/pkgs/development/libraries/libtiff/0001-Disable-OpenGL.patch
new file mode 100644
index 00000000000..60ce8ed49b1
--- /dev/null
+++ b/pkgs/development/libraries/libtiff/0001-Disable-OpenGL.patch
@@ -0,0 +1,26 @@
+From 6385dfa45c86b79da4f84df10f481f0ba260ab1f Mon Sep 17 00:00:00 2001
+From: toonn <toonn@toonn.io>
+Date: Sat, 3 Jul 2021 20:38:25 +0200
+Subject: [PATCH] Disable OpenGL
+
+---
+ CMakeLists.txt | 3 ---
+ 1 file changed, 3 deletions(-)
+
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index efe857d..e72897b 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -611,9 +611,6 @@ endif()
+ find_package(OpenGL)
+ find_package(GLUT)
+ set(HAVE_OPENGL FALSE)
+-if(OPENGL_FOUND AND OPENGL_GLU_FOUND AND GLUT_FOUND)
+-  set(HAVE_OPENGL TRUE)
+-endif()
+ # Purely to satisfy the generated headers:
+ check_include_file(GL/gl.h HAVE_GL_GL_H)
+ check_include_file(GL/glu.h HAVE_GL_GLU_H)
+-- 
+2.17.2 (Apple Git-113)
+
diff --git a/pkgs/development/libraries/libtiff/default.nix b/pkgs/development/libraries/libtiff/default.nix
index ea246790020..d004f35d3f1 100644
--- a/pkgs/development/libraries/libtiff/default.nix
+++ b/pkgs/development/libraries/libtiff/default.nix
@@ -22,7 +22,12 @@ stdenv.mkDerivation rec {
   };
 
   # FreeImage needs this patch
-  patches = [ ./headers.patch ];
+  patches = [ ./headers.patch ]
+    # CMake manages to detect the OpenGL and GLUT system frameworks but doesn't
+    # find the `gl.h` header, making the tests fail. With older Clangs OpenGL
+    # wasn't detected so the simplest fix was to keep CMake from checking for
+    # it. This means `tiffgt` isn't built and tested.
+    ++ lib.optional stdenv.isDarwin ./0001-Disable-OpenGL.patch;
 
   outputs = [ "bin" "dev" "dev_private" "out" "man" "doc" ];