diff --git a/pkgs/development/python-modules/smbus-cffi/default.nix b/pkgs/development/python-modules/smbus-cffi/default.nix
new file mode 100644
index 00000000000..b762730914b
--- /dev/null
+++ b/pkgs/development/python-modules/smbus-cffi/default.nix
@@ -0,0 +1,46 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, cffi
+, pytestCheckHook
+, pyserial
+, fetchpatch
+}:
+
+buildPythonPackage rec {
+  pname = "smbus-cffi";
+  version = "0.5.1";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "fb4195aaabfc01586863f60d3190b5cb1bf8f12622fd597e23e48768dad6bde8";
+  };
+
+  patches = [
+    # https://github.com/bivab/smbus-cffi/pull/24
+    (fetchpatch {
+      url = "https://github.com/bivab/smbus-cffi/commit/ba79ae174a9d84e767d95f165c43ee212b1bbb92.patch";
+      sha256 = "sha256-WtRuK5y6fWDEhm0Xy5XqS5yCkn7vXXYtjlOjS90gla4=";
+    })
+  ];
+
+  propagatedBuildInputs = [ cffi ];
+
+  installCheckPhase = ''
+    # we want to import the installed module that also contains the compiled library
+    rm -rf smbus
+    runHook pytestCheckPhase
+  '';
+
+  # requires hardware access
+  pytestFlagsArray = [ "--ignore=test/test_smbus_integration.py" ];
+
+  checkInputs = [ pytestCheckHook pyserial ];
+
+  meta = with lib; {
+    description = "Python module for SMBus access through Linux I2C /dev interface";
+    homepage = "https://github.com/bivab/smbus-cffi";
+    license = licenses.gpl2;
+    maintainers = with maintainers; [ mic92 ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 2ef9459b13f..80f157dbd4e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -6664,6 +6664,8 @@ in {
 
   smartypants = callPackage ../development/python-modules/smartypants { };
 
+  smbus-cffi = callPackage ../development/python-modules/smbus-cffi { };
+
   smmap2 = throw "smmap2 has been deprecated, use smmap instead."; # added 2020-03-14
 
   smmap = callPackage ../development/python-modules/smmap { };