diff --git a/pkgs/development/python-modules/pygpgme/default.nix b/pkgs/development/python-modules/pygpgme/default.nix
index 29be02751bb..ea6364f1125 100644
--- a/pkgs/development/python-modules/pygpgme/default.nix
+++ b/pkgs/development/python-modules/pygpgme/default.nix
@@ -1,10 +1,18 @@
-{ lib, buildPythonPackage, fetchurl, isPyPy
-, gpgme }:
+{ lib
+, buildPythonPackage
+, fetchurl
+, gpgme
+, isPyPy
+, pythonAtLeast
+}:
 
 buildPythonPackage rec {
   version = "0.3";
   pname = "pygpgme";
-  disabled = isPyPy;
+
+  # Native code doesn't compile against the C API of Python 3.11:
+  # https://bugs.launchpad.net/pygpgme/+bug/1996122
+  disabled = isPyPy || pythonAtLeast "3.11";
 
   src = fetchurl {
     url = "https://launchpad.net/pygpgme/trunk/${version}/+download/${pname}-${version}.tar.gz";