diff --git a/pkgs/development/python-modules/amaranth/default.nix b/pkgs/development/python-modules/amaranth/default.nix
index 938b44202b9..5a3f7e449e2 100644
--- a/pkgs/development/python-modules/amaranth/default.nix
+++ b/pkgs/development/python-modules/amaranth/default.nix
@@ -2,6 +2,7 @@
 , buildPythonPackage
 , pythonOlder
 , fetchFromGitHub
+, fetchpatch
 , setuptools
 , setuptools-scm
 , pyvcd
@@ -31,6 +32,23 @@ buildPythonPackage rec {
     sha256 = "P9AG3t30eGeeCN5+t7mjhRoOWIGZVzWQji9eYXphjA0=";
   };
 
+  patches = [
+    (fetchpatch {
+      name = "fix-for-setuptools-64.0.2-preparation.patch";
+      url = "https://github.com/amaranth-lang/amaranth/commit/64771a065a280fa683c1e6692383bec4f59f20fa.patch";
+      hash = "sha256-Rsh9vVvUQj9nIcrsRirmR6XwFrfZ2VMaYJ4RCQ8sBE0=";
+      # This commit removes support for Python 3.6, which is unnecessary to fix
+      # the build when using new setuptools. Include only one file, which has a
+      # harmless comment change so that the subsequent patch applies cleanly.
+      includes = ["amaranth/_toolchain/cxx.py"];
+    })
+    (fetchpatch {
+      name = "fix-for-setuptools-64.0.2.patch";
+      url = "https://github.com/amaranth-lang/amaranth/pull/722/commits/e5a56b07c568e5f4cc2603eefebd14c5cc4e13d8.patch";
+      hash = "sha256-C8FyMSKHA7XsEMpO9eYNZx/X5rGaK7p3eXP+jSb6wVg=";
+    })
+  ];
+
   SETUPTOOLS_SCM_PRETEND_VERSION="${realVersion}";
 
   nativeBuildInputs = [