diff --git a/pkgs/stdenv/adapters.nix b/pkgs/stdenv/adapters.nix
index 3e66de48b4d..22da13f5d1e 100644
--- a/pkgs/stdenv/adapters.nix
+++ b/pkgs/stdenv/adapters.nix
@@ -105,6 +105,7 @@ rec {
             name = "darwin-portable-libSystem-hook";
             substitutions = {
               libsystem = "${stdenv.cc.libc}/lib/libSystem.B.dylib";
+              targetPrefix = stdenv.cc.bintools.targetPrefix;
             };
           } ./darwin/portable-libsystem.sh)
         ];
diff --git a/pkgs/stdenv/darwin/portable-libsystem.sh b/pkgs/stdenv/darwin/portable-libsystem.sh
index f50ccc8d32e..1fb80c0e5ce 100644
--- a/pkgs/stdenv/darwin/portable-libsystem.sh
+++ b/pkgs/stdenv/darwin/portable-libsystem.sh
@@ -7,6 +7,6 @@ fixupOutputHooks+=('fixLibsystemRefs $prefix')
 fixLibsystemRefs() {
   if [ -d "$1/bin" ]; then
       find "$1/bin" -exec \
-        install_name_tool -change @libsystem@ /usr/lib/libSystem.B.dylib {} \;
+        @targetPrefix@install_name_tool -change @libsystem@ /usr/lib/libSystem.B.dylib {} \;
   fi
 }