diff --git a/Marlin/Conditionals_post.h b/Marlin/Conditionals_post.h
index ca36789960..a0f7233bb3 100644
--- a/Marlin/Conditionals_post.h
+++ b/Marlin/Conditionals_post.h
@@ -279,6 +279,18 @@
     #define HEATER_3_USES_THERMISTOR
   #endif
 
+  #if TEMP_SENSOR_4 <= -2
+    #error "MAX6675 / MAX31855 Thermocouples not supported for TEMP_SENSOR_4"
+  #elif TEMP_SENSOR_4 == -1
+    #define HEATER_4_USES_AD595
+  #elif TEMP_SENSOR_4 == 0
+    #undef HEATER_4_MINTEMP
+    #undef HEATER_4_MAXTEMP
+  #elif TEMP_SENSOR_4 > 0
+    #define THERMISTORHEATER_4 TEMP_SENSOR_4
+    #define HEATER_4_USES_THERMISTOR
+  #endif
+
   #if TEMP_SENSOR_BED <= -2
     #error "MAX6675 / MAX31855 Thermocouples not supported for TEMP_SENSOR_BED"
   #elif TEMP_SENSOR_BED == -1
@@ -427,16 +439,19 @@
   #define HAS_TEMP_1 (PIN_EXISTS(TEMP_1) && TEMP_SENSOR_1 != 0 && TEMP_SENSOR_1 > -2)
   #define HAS_TEMP_2 (PIN_EXISTS(TEMP_2) && TEMP_SENSOR_2 != 0 && TEMP_SENSOR_2 > -2)
   #define HAS_TEMP_3 (PIN_EXISTS(TEMP_3) && TEMP_SENSOR_3 != 0 && TEMP_SENSOR_3 > -2)
+  #define HAS_TEMP_4 (PIN_EXISTS(TEMP_4) && TEMP_SENSOR_4 != 0 && TEMP_SENSOR_4 > -2)
   #define HAS_TEMP_BED (PIN_EXISTS(TEMP_BED) && TEMP_SENSOR_BED != 0 && TEMP_SENSOR_BED > -2)
   #define HAS_HEATER_0 (PIN_EXISTS(HEATER_0))
   #define HAS_HEATER_1 (PIN_EXISTS(HEATER_1))
   #define HAS_HEATER_2 (PIN_EXISTS(HEATER_2))
   #define HAS_HEATER_3 (PIN_EXISTS(HEATER_3))
+  #define HAS_HEATER_4 (PIN_EXISTS(HEATER_4))
   #define HAS_HEATER_BED (PIN_EXISTS(HEATER_BED))
   #define HAS_AUTO_FAN_0 (PIN_EXISTS(E0_AUTO_FAN))
   #define HAS_AUTO_FAN_1 (HOTENDS > 1 && PIN_EXISTS(E1_AUTO_FAN))
   #define HAS_AUTO_FAN_2 (HOTENDS > 2 && PIN_EXISTS(E2_AUTO_FAN))
   #define HAS_AUTO_FAN_3 (HOTENDS > 3 && PIN_EXISTS(E3_AUTO_FAN))
+  #define HAS_AUTO_FAN_4 (HOTENDS > 4 && PIN_EXISTS(E4_AUTO_FAN))
   #define HAS_AUTO_FAN (HAS_AUTO_FAN_0 || HAS_AUTO_FAN_1 || HAS_AUTO_FAN_2 || HAS_AUTO_FAN_3)
   #define AUTO_1_IS_0 (E1_AUTO_FAN_PIN == E0_AUTO_FAN_PIN)
   #define AUTO_2_IS_0 (E2_AUTO_FAN_PIN == E0_AUTO_FAN_PIN)
@@ -444,6 +459,10 @@
   #define AUTO_3_IS_0 (E3_AUTO_FAN_PIN == E0_AUTO_FAN_PIN)
   #define AUTO_3_IS_1 (E3_AUTO_FAN_PIN == E1_AUTO_FAN_PIN)
   #define AUTO_3_IS_2 (E3_AUTO_FAN_PIN == E2_AUTO_FAN_PIN)
+  #define AUTO_4_IS_0 (E4_AUTO_FAN_PIN == E0_AUTO_FAN_PIN)
+  #define AUTO_4_IS_1 (E4_AUTO_FAN_PIN == E1_AUTO_FAN_PIN)
+  #define AUTO_4_IS_2 (E4_AUTO_FAN_PIN == E2_AUTO_FAN_PIN)
+  #define AUTO_4_IS_3 (E4_AUTO_FAN_PIN == E3_AUTO_FAN_PIN)
   #define HAS_FAN0 (PIN_EXISTS(FAN))
   #define HAS_FAN1 (PIN_EXISTS(FAN1) && CONTROLLERFAN_PIN != FAN1_PIN && E0_AUTO_FAN_PIN != FAN1_PIN && E1_AUTO_FAN_PIN != FAN1_PIN && E2_AUTO_FAN_PIN != FAN1_PIN && E3_AUTO_FAN_PIN != FAN1_PIN)
   #define HAS_FAN2 (PIN_EXISTS(FAN2) && CONTROLLERFAN_PIN != FAN2_PIN && E0_AUTO_FAN_PIN != FAN2_PIN && E1_AUTO_FAN_PIN != FAN2_PIN && E2_AUTO_FAN_PIN != FAN2_PIN && E3_AUTO_FAN_PIN != FAN2_PIN)
@@ -543,9 +562,12 @@
       #define WRITE_HEATER_2(v) WRITE(HEATER_2_PIN, v)
       #if HOTENDS > 3
         #define WRITE_HEATER_3(v) WRITE(HEATER_3_PIN, v)
-      #endif
-    #endif
-  #endif
+        #if HOTENDS > 4
+          #define WRITE_HEATER_4(v) WRITE(HEATER_4_PIN, v)
+        #endif // HOTENDS > 4
+      #endif // HOTENDS > 3
+    #endif // HOTENDS > 2
+  #endif // HOTENDS > 1
   #if ENABLED(HEATERS_PARALLEL)
     #define WRITE_HEATER_0(v) { WRITE_HEATER_0P(v); WRITE_HEATER_1(v); }
   #else
diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index bc85cc2fb8..15d7238f5c 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -752,6 +755,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 955110dfd5..660f498460 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/SanityCheck.h b/Marlin/SanityCheck.h
index 301f32735d..63abf9c7cf 100644
--- a/Marlin/SanityCheck.h
+++ b/Marlin/SanityCheck.h
@@ -309,8 +309,8 @@
  */
 #if EXTRUDERS > 1
 
-  #if EXTRUDERS > 4
-    #error "The maximum number of EXTRUDERS in Marlin is 4."
+  #if EXTRUDERS > 5
+    #error "Marlin supports a maximum of 5 EXTRUDERS."
   #endif
 
   #if ENABLED(TEMP_SENSOR_1_AS_REDUNDANT)
@@ -800,19 +800,34 @@ static_assert(1 >= 0
     #endif
     #if HOTENDS > 3
       #if TEMP_SENSOR_3 == 0
-        #error "TEMP_SENSOR_3 is required with 4 HOTENDS."
+        #error "TEMP_SENSOR_3 is required with 4 or more HOTENDS."
       #elif !HAS_HEATER_3
         #error "HEATER_3_PIN not defined for this board."
       #elif !PIN_EXISTS(TEMP_3)
         #error "TEMP_3_PIN not defined for this board."
       #endif
+      #if HOTENDS > 4
+        #if TEMP_SENSOR_4 == 0
+          #error "TEMP_SENSOR_4 is required with 5 HOTENDS."
+        #elif !HAS_HEATER_4
+          #error "HEATER_4_PIN not defined for this board."
+        #elif !PIN_EXISTS(TEMP_4)
+          #error "TEMP_4_PIN not defined for this board."
+        #endif
+      #elif TEMP_SENSOR_4 != 0
+        #error "TEMP_SENSOR_4 shouldn't be set with only 4 extruders."
+      #endif
     #elif TEMP_SENSOR_3 != 0
       #error "TEMP_SENSOR_3 shouldn't be set with only 3 extruders."
+    #elif TEMP_SENSOR_4 != 0
+      #error "TEMP_SENSOR_4 shouldn't be set with only 3 extruders."
     #endif
   #elif TEMP_SENSOR_2 != 0
     #error "TEMP_SENSOR_2 shouldn't be set with only 2 extruders."
   #elif TEMP_SENSOR_3 != 0
     #error "TEMP_SENSOR_3 shouldn't be set with only 2 extruders."
+  #elif TEMP_SENSOR_4 != 0
+    #error "TEMP_SENSOR_4 shouldn't be set with only 2 extruders."
   #endif
 #elif TEMP_SENSOR_1 != 0 && DISABLED(TEMP_SENSOR_1_AS_REDUNDANT)
   #error "TEMP_SENSOR_1 shouldn't be set with only 1 extruder."
@@ -820,6 +835,8 @@ static_assert(1 >= 0
   #error "TEMP_SENSOR_2 shouldn't be set with only 1 extruder."
 #elif TEMP_SENSOR_3 != 0
   #error "TEMP_SENSOR_3 shouldn't be set with only 1 extruder."
+#elif TEMP_SENSOR_4 != 0
+  #error "TEMP_SENSOR_4 shouldn't be set with only 1 extruder."
 #endif
 
 #if ENABLED(TEMP_SENSOR_1_AS_REDUNDANT) && TEMP_SENSOR_1 == 0
@@ -853,7 +870,11 @@ static_assert(1 >= 0
 /**
  * Test Extruder Pins
  */
-#if EXTRUDERS > 3
+#if EXTRUDERS > 4
+  #if !PIN_EXISTS(E4_STEP) || !PIN_EXISTS(E4_DIR) || !PIN_EXISTS(E4_ENABLE)
+    #error "E4_STEP_PIN, E4_DIR_PIN, or E4_ENABLE_PIN not defined for this board."
+  #endif
+#elif EXTRUDERS > 3
   #if !PIN_EXISTS(E3_STEP) || !PIN_EXISTS(E3_DIR) || !PIN_EXISTS(E3_ENABLE)
     #error "E3_STEP_PIN, E3_DIR_PIN, or E3_ENABLE_PIN not defined for this board."
   #endif
diff --git a/Marlin/example_configurations/Cartesio/Configuration.h b/Marlin/example_configurations/Cartesio/Configuration.h
index a11bb7d70b..05c1036bb2 100644
--- a/Marlin/example_configurations/Cartesio/Configuration.h
+++ b/Marlin/example_configurations/Cartesio/Configuration.h
@@ -255,6 +255,7 @@
 #define TEMP_SENSOR_1 -1
 #define TEMP_SENSOR_2 1
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -283,6 +284,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -752,6 +754,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/Cartesio/Configuration_adv.h b/Marlin/example_configurations/Cartesio/Configuration_adv.h
index a9d497e382..2bda7419ab 100644
--- a/Marlin/example_configurations/Cartesio/Configuration_adv.h
+++ b/Marlin/example_configurations/Cartesio/Configuration_adv.h
@@ -221,6 +221,7 @@
 //#define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 35
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/Felix/Configuration.h b/Marlin/example_configurations/Felix/Configuration.h
index f327479d11..1b3704f2e2 100644
--- a/Marlin/example_configurations/Felix/Configuration.h
+++ b/Marlin/example_configurations/Felix/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -735,6 +738,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/Felix/Configuration_adv.h b/Marlin/example_configurations/Felix/Configuration_adv.h
index d1204fc630..e46b3bd5b5 100644
--- a/Marlin/example_configurations/Felix/Configuration_adv.h
+++ b/Marlin/example_configurations/Felix/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/Felix/DUAL/Configuration.h b/Marlin/example_configurations/Felix/DUAL/Configuration.h
index bf60c1be59..771ece9b3e 100644
--- a/Marlin/example_configurations/Felix/DUAL/Configuration.h
+++ b/Marlin/example_configurations/Felix/DUAL/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 1
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -735,6 +738,7 @@
 #define INVERT_E1_DIR true
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/Hephestos/Configuration.h b/Marlin/example_configurations/Hephestos/Configuration.h
index 3c12c03c98..15ad5c2478 100644
--- a/Marlin/example_configurations/Hephestos/Configuration.h
+++ b/Marlin/example_configurations/Hephestos/Configuration.h
@@ -257,6 +257,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -285,6 +286,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -744,6 +746,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/Hephestos/Configuration_adv.h b/Marlin/example_configurations/Hephestos/Configuration_adv.h
index 86ea0fc565..6b0b8ea722 100644
--- a/Marlin/example_configurations/Hephestos/Configuration_adv.h
+++ b/Marlin/example_configurations/Hephestos/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration.h b/Marlin/example_configurations/Hephestos_2/Configuration.h
index e01cc0ee82..9a415d782d 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration.h
@@ -250,10 +250,11 @@
  *
  * :{ '0': "Not used", '1':"100k / 4.7k - EPCOS", '2':"200k / 4.7k - ATC Semitec 204GT-2", '3':"Mendel-parts / 4.7k", '4':"10k !! do not use for a hotend. Bad resolution at high temp. !!", '5':"100K / 4.7k - ATC Semitec 104GT-2 (Used in ParCan & J-Head)", '6':"100k / 4.7k EPCOS - Not as accurate as Table 1", '7':"100k / 4.7k Honeywell 135-104LAG-J01", '8':"100k / 4.7k 0603 SMD Vishay NTCS0603E3104FXT", '9':"100k / 4.7k GE Sensing AL03006-58.2K-97-G1", '10':"100k / 4.7k RS 198-961", '11':"100k / 4.7k beta 3950 1%", '12':"100k / 4.7k 0603 SMD Vishay NTCS0603E3104FXT (calibrated for Makibox hot bed)", '13':"100k Hisens 3950  1% up to 300°C for hotend 'Simple ONE ' & hotend 'All In ONE'", '20':"PT100 (Ultimainboard V2.x)", '51':"100k / 1k - EPCOS", '52':"200k / 1k - ATC Semitec 204GT-2", '55':"100k / 1k - ATC Semitec 104GT-2 (Used in ParCan & J-Head)", '60':"100k Maker's Tool Works Kapton Bed Thermistor beta=3950", '66':"Dyze Design 4.7M High Temperature thermistor", '70':"the 100K thermistor found in the bq Hephestos 2", '71':"100k / 4.7k Honeywell 135-104LAF-J01", '147':"Pt100 / 4.7k", '1047':"Pt1000 / 4.7k", '110':"Pt100 / 1k (non-standard)", '1010':"Pt1000 / 1k (non standard)", '-3':"Thermocouple + MAX31855 (only for sensor 0)", '-2':"Thermocouple + MAX6675 (only for sensor 0)", '-1':"Thermocouple + AD595",'998':"Dummy 1", '999':"Dummy 2" }
  */
-#define TEMP_SENSOR_0   70
-#define TEMP_SENSOR_1   0
-#define TEMP_SENSOR_2   0
-#define TEMP_SENSOR_3   0
+#define TEMP_SENSOR_0 70
+#define TEMP_SENSOR_1 0
+#define TEMP_SENSOR_2 0
+#define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -279,19 +280,21 @@
 // to check that the wiring to the thermistor is not broken.
 // Otherwise this would lead to the heater being powered on all the time.
 #define HEATER_0_MINTEMP 15
-//#define HEATER_1_MINTEMP 5
-//#define HEATER_2_MINTEMP 5
-//#define HEATER_3_MINTEMP 5
-//#define BED_MINTEMP 5
+#define HEATER_1_MINTEMP 5
+#define HEATER_2_MINTEMP 5
+#define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
+#define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
 // This feature exists to protect your hotend from overheating accidentally, but *NOT* from thermistor short/failure!
 // You should use MINTEMP for thermistor short/failure protection.
 #define HEATER_0_MAXTEMP 250
-//#define HEATER_1_MAXTEMP 275
-//#define HEATER_2_MAXTEMP 275
-//#define HEATER_3_MAXTEMP 275
-//#define BED_MAXTEMP 150
+#define HEATER_1_MAXTEMP 275
+#define HEATER_2_MAXTEMP 275
+#define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
+#define BED_MAXTEMP 150
 
 //===========================================================================
 //============================= PID Settings ================================
@@ -746,6 +749,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration_adv.h b/Marlin/example_configurations/Hephestos_2/Configuration_adv.h
index cae6946983..fed37e6c2f 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration_adv.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration_adv.h
@@ -221,6 +221,7 @@
 //#define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/K8200/Configuration.h b/Marlin/example_configurations/K8200/Configuration.h
index 1b6ff0645e..2e78a8c955 100644
--- a/Marlin/example_configurations/K8200/Configuration.h
+++ b/Marlin/example_configurations/K8200/Configuration.h
@@ -274,6 +274,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 5
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -302,6 +303,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -311,6 +313,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -780,6 +783,7 @@
 #define INVERT_E1_DIR true
 #define INVERT_E2_DIR true
 #define INVERT_E3_DIR true
+#define INVERT_E4_DIR true
 
 // @section homing
 // K8200: it is usual to have clamps for the glass plate on the heatbed
diff --git a/Marlin/example_configurations/K8200/Configuration_adv.h b/Marlin/example_configurations/K8200/Configuration_adv.h
index 734e4c6614..3a12e24fca 100644
--- a/Marlin/example_configurations/K8200/Configuration_adv.h
+++ b/Marlin/example_configurations/K8200/Configuration_adv.h
@@ -234,6 +234,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/K8400/Configuration.h b/Marlin/example_configurations/K8400/Configuration.h
index ac16107a53..98cf55e871 100644
--- a/Marlin/example_configurations/K8400/Configuration.h
+++ b/Marlin/example_configurations/K8400/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -752,6 +755,7 @@
 #define INVERT_E1_DIR true
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/K8400/Configuration_adv.h b/Marlin/example_configurations/K8400/Configuration_adv.h
index 06f214726e..9064d2ffdf 100644
--- a/Marlin/example_configurations/K8400/Configuration_adv.h
+++ b/Marlin/example_configurations/K8400/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/K8400/Dual-head/Configuration.h b/Marlin/example_configurations/K8400/Dual-head/Configuration.h
index b40eb460e5..381f771f2b 100644
--- a/Marlin/example_configurations/K8400/Dual-head/Configuration.h
+++ b/Marlin/example_configurations/K8400/Dual-head/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 5
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -752,6 +755,7 @@
 #define INVERT_E1_DIR true
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
index 20ca7ae84c..c86a4f8a32 100644
--- a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
+++ b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -752,6 +755,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/RigidBot/Configuration.h b/Marlin/example_configurations/RigidBot/Configuration.h
index 5ccf190359..4a49291849 100644
--- a/Marlin/example_configurations/RigidBot/Configuration.h
+++ b/Marlin/example_configurations/RigidBot/Configuration.h
@@ -257,6 +257,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -285,6 +286,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -294,6 +296,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -751,6 +754,7 @@
 #define INVERT_E1_DIR true
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/RigidBot/Configuration_adv.h b/Marlin/example_configurations/RigidBot/Configuration_adv.h
index 420b7b8dad..8c21ced0ec 100644
--- a/Marlin/example_configurations/RigidBot/Configuration_adv.h
+++ b/Marlin/example_configurations/RigidBot/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/SCARA/Configuration.h b/Marlin/example_configurations/SCARA/Configuration.h
index f118d361f1..063c1e2471 100644
--- a/Marlin/example_configurations/SCARA/Configuration.h
+++ b/Marlin/example_configurations/SCARA/Configuration.h
@@ -286,6 +286,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -314,6 +315,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -323,6 +325,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -767,6 +770,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/SCARA/Configuration_adv.h b/Marlin/example_configurations/SCARA/Configuration_adv.h
index 22f7ca0755..68f5e427bb 100644
--- a/Marlin/example_configurations/SCARA/Configuration_adv.h
+++ b/Marlin/example_configurations/SCARA/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/TAZ4/Configuration.h b/Marlin/example_configurations/TAZ4/Configuration.h
index 8793a41a15..bf9420d8f0 100644
--- a/Marlin/example_configurations/TAZ4/Configuration.h
+++ b/Marlin/example_configurations/TAZ4/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 7
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 7
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -773,6 +775,7 @@
 #define INVERT_E1_DIR true
 #define INVERT_E2_DIR true
 #define INVERT_E3_DIR true
+#define INVERT_E4_DIR true
 
 // @section homing
 
diff --git a/Marlin/example_configurations/TAZ4/Configuration_adv.h b/Marlin/example_configurations/TAZ4/Configuration_adv.h
index 3fee26733d..f916d6bec6 100644
--- a/Marlin/example_configurations/TAZ4/Configuration_adv.h
+++ b/Marlin/example_configurations/TAZ4/Configuration_adv.h
@@ -229,6 +229,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/TinyBoy2/Configuration.h b/Marlin/example_configurations/TinyBoy2/Configuration.h
index 952d95f135..e99110a2f1 100644
--- a/Marlin/example_configurations/TinyBoy2/Configuration.h
+++ b/Marlin/example_configurations/TinyBoy2/Configuration.h
@@ -276,6 +276,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #if ENABLED(TB2_HEATBED_MOD)
   // K8200 Heatbed 1206/100k/3950K spare part
   #define TEMP_SENSOR_BED 7
@@ -309,6 +310,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -318,6 +320,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 100
 
 //===========================================================================
@@ -802,6 +805,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/TinyBoy2/Configuration_adv.h b/Marlin/example_configurations/TinyBoy2/Configuration_adv.h
index 3bc3a02c79..aba1cb5cd0 100644
--- a/Marlin/example_configurations/TinyBoy2/Configuration_adv.h
+++ b/Marlin/example_configurations/TinyBoy2/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/WITBOX/Configuration.h b/Marlin/example_configurations/WITBOX/Configuration.h
index dd8c3d759a..68c15d8885 100644
--- a/Marlin/example_configurations/WITBOX/Configuration.h
+++ b/Marlin/example_configurations/WITBOX/Configuration.h
@@ -257,6 +257,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -285,6 +286,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -744,6 +746,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/WITBOX/Configuration_adv.h b/Marlin/example_configurations/WITBOX/Configuration_adv.h
index 86ea0fc565..6b0b8ea722 100644
--- a/Marlin/example_configurations/WITBOX/Configuration_adv.h
+++ b/Marlin/example_configurations/WITBOX/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/adafruit/ST7565/Configuration.h b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
index e55e394a13..dc612f96b6 100644
--- a/Marlin/example_configurations/adafruit/ST7565/Configuration.h
+++ b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -752,6 +755,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration.h b/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration.h
index f71c9c4c37..310b102e33 100644
--- a/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 1
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -859,6 +862,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration_adv.h b/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration_adv.h
index 9982b7d38d..1ebf49c8e0 100644
--- a/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/flsun_kossel_mini/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/delta/generic/Configuration.h b/Marlin/example_configurations/delta/generic/Configuration.h
index 2060eace9e..c14266b676 100644
--- a/Marlin/example_configurations/delta/generic/Configuration.h
+++ b/Marlin/example_configurations/delta/generic/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 0
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -843,6 +846,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/delta/generic/Configuration_adv.h b/Marlin/example_configurations/delta/generic/Configuration_adv.h
index 954c6de6e6..661c87ff67 100644
--- a/Marlin/example_configurations/delta/generic/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/generic/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration.h b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
index 4e82838ede..36b95d8c38 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 11
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -838,6 +841,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h b/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h
index 954c6de6e6..661c87ff67 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration.h b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
index 2d3b215020..64ebb80fbb 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
@@ -258,6 +258,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 5
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -286,6 +287,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -295,6 +297,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -845,6 +848,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h b/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h
index 9a6cf9f38c..a352286725 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration_adv.h
@@ -226,6 +226,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration.h b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
index bb0a094abb..dd35df765d 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 5
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -854,6 +857,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h b/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h
index a51d824c22..c9ddf65fe7 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/makibox/Configuration.h b/Marlin/example_configurations/makibox/Configuration.h
index 71df0a5d11..8db0a52a7a 100644
--- a/Marlin/example_configurations/makibox/Configuration.h
+++ b/Marlin/example_configurations/makibox/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 12
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -755,6 +758,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/makibox/Configuration_adv.h b/Marlin/example_configurations/makibox/Configuration_adv.h
index 4dd929522e..c05b8b2fe7 100644
--- a/Marlin/example_configurations/makibox/Configuration_adv.h
+++ b/Marlin/example_configurations/makibox/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed
 
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration.h b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
index d2aaaf147f..8285c43a05 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
@@ -254,6 +254,7 @@
 #define TEMP_SENSOR_1 0
 #define TEMP_SENSOR_2 0
 #define TEMP_SENSOR_3 0
+#define TEMP_SENSOR_4 0
 #define TEMP_SENSOR_BED 5
 
 // Dummy thermistor constant temperature readings, for use with 998 and 999
@@ -282,6 +283,7 @@
 #define HEATER_1_MINTEMP 5
 #define HEATER_2_MINTEMP 5
 #define HEATER_3_MINTEMP 5
+#define HEATER_4_MINTEMP 5
 #define BED_MINTEMP 5
 
 // When temperature exceeds max temp, your heater will be switched off.
@@ -291,6 +293,7 @@
 #define HEATER_1_MAXTEMP 275
 #define HEATER_2_MAXTEMP 275
 #define HEATER_3_MAXTEMP 275
+#define HEATER_4_MAXTEMP 275
 #define BED_MAXTEMP 150
 
 //===========================================================================
@@ -748,6 +751,7 @@
 #define INVERT_E1_DIR false
 #define INVERT_E2_DIR false
 #define INVERT_E3_DIR false
+#define INVERT_E4_DIR false
 
 // @section homing
 
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h b/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h
index 3efc63760e..0dc3b7860b 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration_adv.h
@@ -221,6 +221,7 @@
 #define E1_AUTO_FAN_PIN -1
 #define E2_AUTO_FAN_PIN -1
 #define E3_AUTO_FAN_PIN -1
+#define E4_AUTO_FAN_PIN -1
 #define EXTRUDER_AUTO_FAN_TEMPERATURE 50
 #define EXTRUDER_AUTO_FAN_SPEED   255  // == full speed